{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:01:43Z","timestamp":1785142903858,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003356","name":"Gazi \u00dcniversitesi","doi-asserted-by":"publisher","award":["FYL\u20102023\u20108706"],"award-info":[{"award-number":["FYL\u20102023\u20108706"]}],"id":[{"id":"10.13039\/501100003356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A new series of extended\u2010functionality triazole\u2010substituted chalcone derivatives was synthesized, and their\n                    <jats:italic>in vitro<\/jats:italic>\n                    anti\u2010proliferative and cytotoxic profiles were evaluated using cancer and non\u2010cancer cell models. First, all compounds were screened in the FaDu head and neck squamous cell carcinoma cell line to identify the most active candidates with comparatively lower IC\n                    <jats:sub>50<\/jats:sub>\n                    values. Compounds\n                    <jats:bold>6c<\/jats:bold>\n                    ,\n                    <jats:bold>6e<\/jats:bold>\n                    , and\n                    <jats:bold>6f<\/jats:bold>\n                    reduced FaDu cell viability to 42.62\u2009\u00b1\u200912.21%, 34.49\u2009\u00b1\u20094.99%, and 31.13\u2009\u00b1\u20094.76% of control, respectively. These three compounds also decreased viability of CaCo\u20102 human colon cancer cells and A549 human lung adenocarcinoma cells, showing micromolar\u2010range activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009&lt;\u200950\u2009\u00b5M) across cancer cell lines of different origins. To obtain a preliminary indication of selectivity, we additionally tested a non\u2010cancer, immortalized prostate epithelial cell line (PNT1a). In this model,\n                    <jats:bold>6c<\/jats:bold>\n                    \/\n                    <jats:bold>6e<\/jats:bold>\n                    \/\n                    <jats:bold>6f<\/jats:bold>\n                    displayed relatively lower cytotoxicity than in cancer cells, suggesting a preliminary selectivity window within the tested assay framework. Among them,\n                    <jats:bold>6f<\/jats:bold>\n                    the most active compound in our series\u2014significantly reduced colony formation, comparable to paclitaxel. In apoptosis\u2010related assessments,\n                    <jats:bold>6f<\/jats:bold>\n                    increased apoptosis\u2010associated readouts in cancer cells relative to control, although further confirmation is needed with additional orthogonal assays. Overall, our results identify\n                    <jats:bold>6c<\/jats:bold>\n                    ,\n                    <jats:bold>6e<\/jats:bold>\n                    , and especially\n                    <jats:bold>6f<\/jats:bold>\n                    as moderately active lead compounds for further optimization of triazole\u2010chalcone hybrids and support continued structure\u2013activity\u2010guided development to improve potency and selectivity.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70291","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:59:49Z","timestamp":1783429189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["1,2,3\u2010Triazole\u2010Linked Chalcones as Privileged Scaffolds in Anticancer Agents"],"prefix":"10.1002","volume":"359","author":[{"given":"Sumeyya","family":"Koldas","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Gazi University  Ankara T\u00fcrkiye"},{"name":"Department of Chemistry, Graduate School of Natural and Applied Sciences Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-6391","authenticated-orcid":false,"given":"Guler Yagiz","family":"Erdemir","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsen","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Erzurum Technical University  Erzurum T\u00fcrkiye"},{"name":"Department of Molecular Cancer Biology Laboratory, High Technology Application and Research Center Erzurum Technical University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslisah","family":"Barlak","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Erzurum Technical University  Erzurum T\u00fcrkiye"},{"name":"Department of Molecular Cancer Biology Laboratory, High Technology Application and Research Center Erzurum Technical University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer Faruk","family":"Karatas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Erzurum Technical University  Erzurum T\u00fcrkiye"},{"name":"Department of Molecular Cancer Biology Laboratory, High Technology Application and Research Center Erzurum Technical University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliye","family":"Altundas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2024.07.027"},{"issue":"8","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20892\/j.issn.2095-3941.2024.0159","article-title":"Global, Regional, and National Burden of Early\u2010Onset Gastric Cancer","volume":"21","author":"Tan N.","year":"2024","journal-title":"Cancer Biology & 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