{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:31:49Z","timestamp":1791221509854,"version":"4.1.0"},"reference-count":125,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic inflammation, arising from unregulated inflammatory responses to tissue damage, is linked to 25% of all cancers. Some new benzofuran\u2010thiazole hybrids,\n                    <jats:bold>H1\u2013H4<\/jats:bold>\n                    , were prepared herein and assessed as dual anticancer and anti\u2010inflammatory agents. All hybrids tested displayed good potency against Caco2 cells. Particularly,\n                    <jats:bold>H4<\/jats:bold>\n                    outperformed doxorubicin in potency, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 0.24\u2009\u03bcM. Moreover,\n                    <jats:bold>H2<\/jats:bold>\n                    and\n                    <jats:bold>H3<\/jats:bold>\n                    exhibited excellent antiproliferative activity against RAW 264.7 cells, which was found comparable to celecoxib, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 160.75 and 115.76\u2009\u03bcM, respectively. The safety of the new hybrids was evaluated against HFB4 cells, as we found that\n                    <jats:bold>H2<\/jats:bold>\n                    and\n                    <jats:bold>H3<\/jats:bold>\n                    showed superior selectivity against cancer cells.\n                    <jats:bold>H2<\/jats:bold>\n                    and\n                    <jats:bold>H3<\/jats:bold>\n                    were found to significantly increase apoptosis in RAW 264.7 cells, confirming their potential as cytotoxic agents. The anti\u2010inflammatory efficacy of some hybrids was screened. The inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)\u2010stimulated RAW 264.7 cells was measured to assess the anti\u2010inflammatory effects, where\n                    <jats:bold>H2<\/jats:bold>\n                    showed significant inhibition at a dose of 100\u2009\u00b5M. Also,\n                    <jats:bold>H3<\/jats:bold>\n                    exhibited comparable cyclooxygenase\u20102 (COX\u20102) inhibitory potency to celecoxib with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 0.69\u2009\u03bcM. At a dose of 1\/20 LD\n                    <jats:sub>50<\/jats:sub>\n                    , both\n                    <jats:bold>H2<\/jats:bold>\n                    and\n                    <jats:bold>H3<\/jats:bold>\n                    were safe for kidney function in an animal model. However,\n                    <jats:bold>H2<\/jats:bold>\n                    was safer for gastric tissue, while\n                    <jats:bold>H3<\/jats:bold>\n                    showed adverse gastric effects at this same concentration. The molecular docking of both hybrids displayed important binding modes with the mouse COX\u20102 (PDB ID: 7O37).\n                  <\/jats:p>","DOI":"10.1002\/ardp.70293","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:18:37Z","timestamp":1783081117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual Anti\u2010Cancer and Anti\u2010Inflammatory Activity of Some New Benzofuran\u2010Thiazole Hybrids With Promising COX\u20102 Inhibitory Potency: Cell\u2010Cycle Arrest, Apoptosis, and Safety Study"],"prefix":"10.1002","volume":"359","author":[{"given":"Romany A.","family":"Badry","sequence":"first","affiliation":[{"name":"Chemistry Department (Biochemistry Division), Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif M. 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