{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:01:31Z","timestamp":1785142891082,"version":"3.55.0"},"reference-count":100,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>FMS\u2010like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase (RTK) important for hematopoietic stem cell proliferation, differentiation, and survival. Ligand\u2010induced dimerization activates the downstream pathways such as RAS\/MAPK, PI3K\/AKT, and STAT5. Mutations such as internal tandem duplications (ITD) and tyrosine kinase domain (TKD) cause constitutive activation, poor prognosis, and driving leukemogenesis in acute myeloid leukemia (AML). Over the past 5 years, FLT3\u2010targeted therapy has advanced significantly. Second\u2010generation FLT3 inhibitors such as gilteritinib and quizartinib displayed improved selectivity and durable efficacy. Quizartinib was approved in 2023 for FLT3\u2010ITD\u2013positive AML alongside intensive chemotherapy. Clinical trials have explored some compounds such as crenolanib, momelotinib, and various novel molecules in combination regimens, which are enhancing remission rates. This review comprehensively compiles diverse chemical scaffolds investigated as FLT3 inhibitors such as pyrimidine, benzimidazole, imidazole, indole, isoxazole, quinazoline, and so on. Structure\u2013activity relationship (SAR) analyses and molecular docking studies are briefly discussed along with highlighting potency against FLT3\u2010ITD and resistant FLT3\u2010TKD mutants. Despite therapeutic gains, resistance through secondary mutations or compensatory pathway activation remains a challenge. Future directions should focus on structure\u2010guided design, rational combination therapies, and expanding applications to other FLT3\u2010altered malignancies. This review integrates updated FLT3 biology, clinical outcomes, medicinal chemistry, and computational insights to support personalized FLT3\u2010targeted treatment strategies.<\/jats:p>","DOI":"10.1002\/ardp.70302","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:09:45Z","timestamp":1783494585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medicinal Insights Into FLT3 Inhibitors as Anticancer Agents: Current Status and Future Direction"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-9457","authenticated-orcid":false,"given":"Ankush","family":"Kumar","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University Rajpura  Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0101-1064","authenticated-orcid":false,"given":"Pallvi","family":"Kumari","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences CT University Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-2080","authenticated-orcid":false,"given":"Keshav Raj","family":"Paudel","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute and School of Science Western Sydney University Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajwinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University Rajpura  Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-8749","authenticated-orcid":false,"given":"Rohit","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University Rajpura  Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-022-01021-8"},{"issue":"4","key":"e_1_2_13_3_1","first-page":"328","article-title":"Acute Myeloid Leukemia\u2014Genetic Alterations and Their Clinical Prognosis","volume":"11","author":"Lagunas\u2010Rangel F. 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