{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:16:45Z","timestamp":1785244605506,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["151818\/2024\u20100"],"award-info":[{"award-number":["151818\/2024\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Many naturally occurring substances exhibit anti\u2010ulcer properties. One promising area of research is the identification of terpenoid compounds with enhanced therapeutic and gastroprotective properties. The present study aimed to synthesize new terpenoid derivatives of myrtenol via biotransformation using freeze\u2010dried\n                    <jats:italic>Cladosporium cladosporioides<\/jats:italic>\n                    mycelium or via porphyrin\u2010based biomimetic transformation, and to evaluate their gastroprotective activity in an ethanol\u2010induced gastric lesion model. Five myrtenyl esters (acetate, butyrate, caprylate, pelargonate, and laurate) and two oxidative derivatives (myrtenal and myrtenal oxide) were obtained with a high degree of purity (&gt;\u200994%, GC). The anti\u2010ulcer preventive effects of the compounds were evaluated in mice at doses ranging from 6.25 to 25\u2009mg per kg of body weight. The mice were treated orally prior to the induction of ethanol\u2010induced gastric lesions. All compounds exerted a gastroprotective effect, reducing the lesion area (mm\n                    <jats:sup>2<\/jats:sup>\n                    ) compared to the negative control group. Notably, the gastroprotective effects of myrtenyl caprylate, myrtenyl pelargonate, and myrtenyl laurate were equivalent to those promoted by the clinical medicine pantoprazole.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70304","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:30:58Z","timestamp":1783924258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastroprotective Activity of Myrtenol Derivatives Obtained by Biocatalytic Esterification and Photooxidation"],"prefix":"10.1002","volume":"359","author":[{"given":"Ana Fl\u00e1via Seraine Cust\u00f3dio","family":"Viana","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Program of Pharmacology Federal University of Piau\u00ed Teresina Piau\u00ed Brazil"},{"name":"Medicinal Plants Research Center (NPPM), Health Sciences Center Federal University of Piau\u00ed Teresina Piau\u00ed Brazil"},{"name":"State University of Maranh\u00e3o Campus Santa In\u00eas Maranh\u00e3o Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Kuty\u0142a","sequence":"additional","affiliation":[{"name":"Department of Industrial and Environmental Microbiology, Faculty of Biology and Biotechnology, Institute of Biological Sciences Maria Curie\u2010Sk\u0142odowska University Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio","family":"de Barros Fernandes","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center (NPPM), Health Sciences Center Federal University of Piau\u00ed Teresina Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris Timah","family":"Acha","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center (NPPM), Health Sciences Center Federal University of Piau\u00ed Teresina Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9808-8203","authenticated-orcid":false,"given":"Gabriel Henrique","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center (NPPM), Health Sciences Center Federal University of Piau\u00ed Teresina Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"de C\u00e1ssia Meneses Oliveira","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program of Pharmacology Federal University of Piau\u00ed Teresina Piau\u00ed Brazil"},{"name":"Medicinal Plants Research Center (NPPM), Health Sciences Center Federal University of Piau\u00ed Teresina Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-6774","authenticated-orcid":false,"given":"Marek","family":"Stankevi\u010d","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Crystallochemistry, Faculty of Chemistry, Institute of Chemistry Sciences Maria Curie\u2010Sk\u0142odowska University Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-7737","authenticated-orcid":false,"given":"Mariusz","family":"Trytek","sequence":"additional","affiliation":[{"name":"Department of Industrial and Environmental Microbiology, Faculty of Biology and Biotechnology, Institute of Biological Sciences Maria Curie\u2010Sk\u0142odowska University Lublin 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