{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:02:29Z","timestamp":1789491749179,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, 20 novel biphenyl\u2010sulfonamide\u2010indole\u2010based thiosemicarbazone derivatives\n                    <jats:bold>(1\u201320)<\/jats:bold>\n                    were synthesized and evaluated for their inhibitory activities against AChE, hCA I, and hCA II. Among the synthesized compounds, compound\n                    <jats:bold>20<\/jats:bold>\n                    (4\u2010nitrophenyl substituted) exhibited the highest inhibitory activity against all three enzymes (AChE\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    \u2009=\u200954.24\u2009nM; hCA I\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    \u2009=\u200912.75\u2009nM; hCA II\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    \u2009=\u20098.72\u2009nM) and behaved as a competitive inhibitor in enzyme kinetic studies. To further explore the experimentally observed AChE inhibition, induced fit docking (IFD), MM\u2010GBSA calculations, and molecular dynamics simulations were performed for compound\n                    <jats:bold>20<\/jats:bold>\n                    , suggesting a plausible binding mode within the AChE active site. In silico ADME analysis indicated generally favorable drug\u2010like properties for the synthesized compounds. These findings identify biphenyl\u2010sulfonamide\u2010indole\u2010based thiosemicarbazones as promising AChE and carbonic anhydrase inhibitors for further biological investigation.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70315","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:32:14Z","timestamp":1786613534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Biological Evaluation of Biphenylsulfonyl Indole\u2010Based Thiosemicarbazones as Potential AChE and CA I\u2010II Inhibitors"],"prefix":"10.1002","volume":"359","author":[{"given":"Fatima","family":"Yaqoob","sequence":"first","affiliation":[{"name":"Institute of Chemical Sciences Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2966-9231","authenticated-orcid":false,"given":"Nastaran","family":"Sadeghian","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bartin University  Bartin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5532-8802","authenticated-orcid":false,"given":"Feyzi Sinan","family":"Tokali","sequence":"additional","affiliation":[{"name":"Department of Material and Material Processing Technologies, Kars Vocational School Kafkas University  Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bartin University  Bartin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel Qlayel","family":"Alkhedaide","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences Turabah University College, Taif University  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiysha","family":"Althobaiti","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine Taif University  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0820-5372","authenticated-orcid":false,"given":"Orhan","family":"Ulucay","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering and Architecture Kafkas University  Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-009X","authenticated-orcid":false,"given":"Mohamed M.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Kafrelsheikh University  Kafr El\u2010Sheikh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-9202","authenticated-orcid":false,"given":"Magdi E. 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