{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:02:29Z","timestamp":1789491749730,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Breast cancer remains the most prevalent malignancy among women worldwide and continues to present major therapeutic challenges, including drug resistance, systemic toxicity, and limited long\u2010term efficacy despite advances in multimodal treatment strategies. These limitations have intensified interest in venom\u2010derived peptides as structurally diverse bioactive scaffolds with anticancer potential. This review evaluates venom\u2010derived peptides in breast cancer from a medicinal chemistry and translational drug development perspective. A structured narrative synthesis of the literature was conducted, covering preclinical and early translational studies of peptides derived from snakes, spiders, scorpions, and bees, with emphasis on structure\u2013function relationships, mechanisms of action, and optimization strategies. Unlike previous reviews that primarily focus on individual venom sources, this work integrates mechanistic pharmacology with peptide engineering and translational constraints to provide a unified drug\u2010development framework across breast cancer subtypes. Venom\u2010derived peptides exert anticancer effects through ion channel modulation, apoptosis induction, cell cycle arrest, angiogenesis inhibition, membrane disruption, and immune modulation, with reported selectivity toward malignant cells in triple\u2010negative, HER2\u2010positive, and hormone receptor\u2010positive models. Despite encouraging preclinical evidence, clinical translation is limited by instability, immunogenicity, poor pharmacokinetics, delivery barriers, and manufacturing challenges. Emerging advances in peptide engineering, nanodelivery systems, and artificial intelligence\u2010assisted design offer promising strategies to improve pharmacological performance and drug\u2010like properties. Overall, this review provides a medicinal chemistry\u2010guided framework that identifies the key steps and remaining challenges required to support the future development of venom\u2010derived peptides as anticancer lead scaffolds for breast cancer.<\/jats:p>","DOI":"10.1002\/ardp.70320","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:55:51Z","timestamp":1786964151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Venom\u2010Derived Peptides in Breast Cancer: Pharmacological Mechanisms and Medicinal Chemistry\u2010Guided Translational Development"],"prefix":"10.1002","volume":"359","author":[{"given":"Radwa A.","family":"Amen","sequence":"first","affiliation":[{"name":"Biotechnology Department, Faculty of Science Cairo University Cairo 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