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To combat the scarcity and limitations of current treatment options, we developed a new class of anti\u2010infective agents against\n                    <jats:italic>Acanthamoeba spp<\/jats:italic>\n                    . based on Ro 48\u20108071 (\n                    <jats:bold>3<\/jats:bold>\n                    ), a known inhibitor of the human oxidosqualene cyclase (hOSC). The compound design was guided by docking studies using a homology model of the cycloartenol synthase (CAS), which is the homolog of hOSC found in\n                    <jats:italic>Acanthamoeba spp<\/jats:italic>\n                    . and essential for the parasite's steroid biosynthesis. Among the synthesized Ro 48\u20108071 analogues, MSHG19 (\n                    <jats:bold>4f<\/jats:bold>\n                    ) evoked the most potent activity against\n                    <jats:italic>Acanthamoeba hatchetti<\/jats:italic>\n                    leading to total eradication of trophozoites and cysts at single\u2010digit micromolar concentrations, whereas having no effects within this concentration range on the viability of human corneal epithelial cells. With our initial set of synthesized compounds, we established a first structure\u2013activity relationship model, which nicely aligns with the predicted binding mode of\n                    <jats:bold>4f<\/jats:bold>\n                    to CAS. Overall, the presented findings highlight the potential of benzophenones as a new class of anti\u2010infectives for the treatment of\n                    <jats:italic>Acanthamoeba<\/jats:italic>\n                    keratitis.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70321","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:13:36Z","timestamp":1787231616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Benzophenone Derivatives as a New Class of Anti\u2010Infectives Against\n                    <i>Acanthamoeba spp<\/i>"],"prefix":"10.1002","volume":"359","author":[{"given":"Tomas","family":"Rimkus","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Technology and Biopharmaceutics Technische Universit\u00e4t Braunschweig Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0989-7774","authenticated-orcid":false,"given":"Hannes","family":"Geisler","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8399-1557","authenticated-orcid":false,"given":"Taha B.","family":"El\u2010Jourani","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-2016","authenticated-orcid":false,"given":"Aur\u00e9lien F. 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