{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:07:48Z","timestamp":1790690868776,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vascular endothelial growth factor receptor 2 (VEGFR\u20102) is a major mediator of pathological angiogenesis, which is critical to tumor progression and metastasis; therefore, inhibition of VEGFR\u20102 remains a key therapeutic strategy for cancer. Despite the established clinical efficacy of several approved VEGFR\u20102\u2010targeted agents, many first\u2010generation inhibitors are limited by dose\u2010limiting toxicities and the emergence of resistance, highlighting an ongoing need for next\u2010generation compounds with improved selectivity and more favorable safety profiles. Among nitrogen\u2010containing heterocyclic frameworks, triazoles and imidazoles are widely employed in medicinal chemistry owing to their favorable structural features, including appropriate stability, synthetic accessibility, and the ability to engage in key molecular interactions. This review summarizes recent advances in the design of triazole\u2010 and imidazole\u2010based VEGFR\u20102 inhibitors, containing Schiff bases, bicyclic, tricyclic, and glycoside derivatives. We comparatively describe their VEGFR\u20102 inhibitory activities and anticancer cytotoxicity data, and discuss key structure\u2010activity relationships and mechanistic insights, with particular emphasis on molecular features that appear to favor potent and selective VEGFR\u20102 inhibition. This review compiles in vitro, in vivo, and in silico data on triazole\u2010 and imidazole\u2010based VEGFR\u20102 inhibitors, providing a basis for understanding trends relevant to the design and development of optimized anti\u2010angiogenic agents.<\/jats:p>","DOI":"10.1002\/ardp.70330","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:44:32Z","timestamp":1790145872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Triazole\u2010 and Imidazole\u2010Containing Compounds: Versatile VEGFR\u20102 Inhibitors for Cancer Therapy"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-932X","authenticated-orcid":false,"given":"Parisa","family":"Nikfar","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Tehran University of Medical Sciences  Tehran 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