{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:07:19Z","timestamp":1790690839723,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The multi\u2010target inhibition of two significant cancer drug targets, cathepsin B and human carbonic anhydrase (hCA) isoforms IX and XII has been explored. The exclusive synthesis of single isomeric structure of final compounds despite two possibilities, in vitro biological studies, in silico molecular docking, DFT and ADMET studies of a small library of 28 new benzenesulfonamides incorporating the 1,2,3\u2010triazolylpyrazole motif are reported. The tumor\u2010associated isoforms hCA IX and hCA XII have been remarkably inhibited in the low nanomolar range, while enzymatically important off\u2010target isoforms hCA I and II were weakly inhibited by most of the synthesized sulfonamides. Overall, respectively, three (K\n                    <jats:sub>I<\/jats:sub>\n                    \u2009&lt;\u200925\u2009nM) and two compounds (K\n                    <jats:sub>I<\/jats:sub>\n                    \u2009&lt;\u20095.7\u2009nM) showed better inhibition of hCA IX and XII as compared with reference drug acetazolamide. Compound\n                    <jats:bold>9f<\/jats:bold>\n                    exhibited 35\u2010fold and eightfold better hCA I\/IX and hCA I\/XII inhibition selectivity, respectively, as compared with SLC\u20100111. Likewise, all the synthesized compounds were also assayed for their inhibition profile against cathepsin B. Some compounds exhibited better inhibition of cathepsin B as compared with reference compound curcumin. In vitro cytotoxicity studies targeting non\u2010cancerous Vero cells (green monkey kidney cells) and cancerous A549 cells (human lung adenocarcinoma cells) have also been performed, which showed interesting results.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70337","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:52:46Z","timestamp":1790059966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multitargeted Anticancer Activities: Cathepsin B\u2013Carbonic Anhydrase IX\/XII Inhibitors Show Enhanced Cytotoxicity Against Lung Adenocarcinoma Cells"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0241-4528","authenticated-orcid":false,"given":"Lalit","family":"Vats","sequence":"first","affiliation":[{"name":"Department of Chemistry Kurukshetra University Kurukshetra Haryana India"},{"name":"Department of Chemistry Government 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6613-1634","authenticated-orcid":false,"given":"Pawan K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Central University of Haryana Mahendergarh Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01599"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061960"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0188-9"},{"key":"e_1_2_9_5_1","first-page":"451","article-title":"Global Cancer Statistics 2022: The Trends Projection Analysis","volume":"10","author":"Chhikara B.","year":"2022","journal-title":"Chemical Biology 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