{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:09:04Z","timestamp":1790690944324,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Naringenin, a prominent member of the flavanone family of polyphenols, is widely distributed in cherries, tomatoes, and citrus fruits, such as grapefruits, as well as in medicinal plants. In vitro and in vivo investigations have shown that naringenin, naringenin\u2010loaded nanoparticles, and its derivatives, whether administered singularly or in conjunction with other anticancer agents, can effectively counteract carcinogenic agents and inhibit the advancement of various malignancies, including colon cancer, lung neoplasms, ovarian cancer, and breast cancer. In this study, the effects of naringenin\u2010benzylpiperazines (\n                    <jats:bold>3b<\/jats:bold>\n                    ,\n                    <jats:bold>3f<\/jats:bold>\n                    , and\n                    <jats:bold>3g<\/jats:bold>\n                    ) were investigated on breast ductal carcinoma MCF7 (ER\u2010\u03b1+), human breast adenocarcinoma SK\u2010Br, human triple\u2010negative breast metastatic adenocarcinoma MDA\u2010MB\u2010231, ovarian cancer NIH\u2010OVCAR\u20103, and human ovarian cancer SKOV\u20103 cells. The IC\n                    <jats:sub>50<\/jats:sub>\n                    values of\n                    <jats:bold>3b<\/jats:bold>\n                    ,\n                    <jats:bold>3f<\/jats:bold>\n                    , and\n                    <jats:bold>3g<\/jats:bold>\n                    were found to be between 31.39 and 73.60\u2009\u00b5M, 29.11 and 86.91\u2009\u00b5M, and 23.53 and 88.63\u2009\u00b5M, respectively. The data obtained indicate that compound\n                    <jats:bold>3f<\/jats:bold>\n                    may be a molecule with the potential to trigger mitochondrial apoptosis in cancer cell lines in a dose\u2010dependent manner by modulating hypoxia, angiogenesis, and JAK\/STAT signaling pathways. In addition, the potential therapeutic value of the compound and its interaction mechanisms with molecular targets have been investigated through theoretical (in silico) calculations.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70339","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:51:09Z","timestamp":1790059869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the Targeted Therapeutic Potential of Naringenin\u2010Benzyl Piperazine Derivatives on Hypoxia\u2010Induced JAK\/STAT Pathway in Breast and Ovarian Cancers"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8031-6755","authenticated-orcid":false,"given":"Hafize","family":"\u00d6zcan","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Trakya University Edirne 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