{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:52:11Z","timestamp":1791445931879,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Breast cancer (BC) is the most common cancer in women worldwide. Natural compounds have been studied to improve chemotherapy efficiency. Cafestol and kahweol (C&amp;K) are diterpenes from coffee lipid fraction, with potential anticancer activity, whose effects and association with chemotherapeutic drug doxorubicin in BC cells are still unknown. Here, we evaluated the synergistic cytotoxic effects of the C&amp;K with doxorubicin and their molecular mechanisms in BC cells. Cell viability was assessed by the MTT assay. Flow cytometry was used to analyze apoptosis, cell cycle, and NF\u2010\u03baB levels. The microarray assay was performed to identify altered signaling pathways, and molecular docking was utilized to predict the interaction between C&amp;K and TNF\u2010\u03b1. In addition, TCGA data were explored to evaluate the clinical association between the expression of C&amp;K\u2010regulated genes and TNF\u2010\u03b1\/NF\u2010\u03baB pathway genes. C&amp;K was cytotoxic and increased the doxorubicin cytotoxicity, augmented the sub\u2010G0\/G1 phase, downregulated TNF\u2010\u03b1\/NF\u2010\u03baB pathway, decreased NF\u2010\u03baB protein levels, and showed affinity for TNF\u2010\u03b1 by molecular docking. Moreover, considering the C&amp;K\u2010modulated genes,\n                    <jats:italic>BLOC1S1<\/jats:italic>\n                    acted as a protective factor for BC, and these genes were negatively correlated with TNF\u2010\u03b1\/NF\u2010\u03baB genes. Our data suggest that C&amp;K have cytotoxic properties by inhibiting TNF\u2010\u03b1\/NF\u2010\u03baB pathway and interacting synergistically with doxorubicin in BC cells.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70359","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:59:46Z","timestamp":1791442786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Cytotoxicity of Cafestol and Kahweol With Doxorubicin in Breast Cancer Cells Involves TNF\u2011\u03b1 Targeting and NF\u2011\u03baB Downregulation"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2117-3448","authenticated-orcid":false,"given":"Layane D.","family":"Souza","sequence":"first","affiliation":[{"name":"Department of Biophysics and Biometrics, Roberto Alcantara Biology Institute State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2849-7875","authenticated-orcid":false,"given":"F\u00e1bio Junior M.","family":"Novaes","sequence":"additional","affiliation":[{"name":"Chemistry Department Vi\u00e7osa Federal University Vi\u00e7osa Brazil"},{"name":"Aromas Analysis Laboratory, Chemical Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-8222","authenticated-orcid":false,"given":"Carlos Luan A.","family":"Passos","sequence":"additional","affiliation":[{"name":"Functional Foods Laboratory, Nutrition Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-1400","authenticated-orcid":false,"given":"\u00cdsis S. S.","family":"de Amorim","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biometrics, Roberto Alcantara Biology Institute State University of Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Functional Foods Laboratory, Nutrition Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-2120","authenticated-orcid":false,"given":"Pedro","family":"Nicolau\u2010Neto","sequence":"additional","affiliation":[{"name":"Molecular Carcinogenesis Program, National Cancer Institute Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4139-4080","authenticated-orcid":false,"given":"Juliana A.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biometrics, Roberto Alcantara Biology Institute State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-1778","authenticated-orcid":false,"given":"Adilson F.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biometrics, Roberto Alcantara Biology Institute State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-0354","authenticated-orcid":false,"given":"Christian","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Functional Foods Laboratory, Nutrition Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia Alexia N.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Functional Foods Laboratory, Nutrition Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-2119","authenticated-orcid":false,"given":"Priscila G.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis of Medicinal Molecules, Chemistry Department State University of Londrina Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6001-360X","authenticated-orcid":false,"given":"Marcelle L. F.","family":"Bispo","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis of Medicinal Molecules, Chemistry Department State University of Londrina Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-7809","authenticated-orcid":false,"given":"Camilo Henrique S.","family":"Lima","sequence":"additional","affiliation":[{"name":"Chemistry Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0429-7871","authenticated-orcid":false,"given":"Bruno Ricardo B.","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biometrics, Roberto Alcantara Biology Institute State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4441-4008","authenticated-orcid":false,"given":"Adenilson de Sousa da","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biometrics, Roberto Alcantara Biology Institute State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-5702","authenticated-orcid":false,"given":"Claudia M.","family":"Rezende","sequence":"additional","affiliation":[{"name":"Aromas Analysis Laboratory, Chemical Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-0021","authenticated-orcid":false,"given":"Eliane","family":"Fialho","sequence":"additional","affiliation":[{"name":"Functional Foods Laboratory, Nutrition Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3229-8094","authenticated-orcid":false,"given":"Andre Luiz","family":"Mencalha","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biometrics, Roberto Alcantara Biology Institute State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_9_3_1","first-page":"10","article-title":"Cancer Statistics, 2025","volume":"75","author":"Siegel R. L.","year":"2025","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3390\/cells12040659","article-title":"Doxorubicin\u2014An Agent With Multiple Mechanisms of Anticancer Activity","volume":"12","author":"Kciuk M.","year":"2023","journal-title":"Cells"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/bph.14816","article-title":"Natural Compounds as Potential Adjuvants to Cancer Therapy: Preclinical Evidence","volume":"177","author":"Lin S. R.","year":"2019","journal-title":"British Journal of Pharmacology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e09519","article-title":"Synergistic Effects of Natural Compounds and Conventional Chemotherapeutic Agents: Recent Insights for the Development of Cancer Treatment Strategies","volume":"8","author":"Casta\u00f1eda A. M.","year":"2022","journal-title":"Heliyon"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0278-6915(02)00029-7","article-title":"Cafestol and Kahweol, Two Coffee Specific Diterpenes With Anticarcinogenic Activity","volume":"40","author":"Cavin C.","year":"2002","journal-title":"Food and Chemical Toxicology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023407","article-title":"Anti\u2010Angiogenic and Anti\u2010Inflammatory Properties of Kahweol, a Coffee Diterpene","volume":"6","author":"C\u00e1rdenas C.","year":"2011","journal-title":"PLoS One"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS20174238"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.bbrc.2014.04.026","article-title":"Insights on the Antitumor Effects of Kahweol on Human Breast Cancer: Decreased Survival and Increased Production of Reactive Oxygen Species and Cytotoxicity","volume":"447","author":"C\u00e1rdenas C.","year":"2014","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.472","article-title":"Cafestol Overcomes ABT\u2010737 Resistance in Mcl\u20101\u2010Overexpressed Renal Carcinoma Caki Cells Through Downregulation of Mcl\u20101 Expression and Upregulation of Bim Expression","volume":"5","author":"Woo S. M.","year":"2014","journal-title":"Cell Death & Disease"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00066-014-0807-x","article-title":"Effect of the Coffee Ingredient Cafestol on Head and Neck Squamous Cell Carcinoma Cell Lines","volume":"191","author":"Kotowski U.","year":"2015","journal-title":"Strahlentherapie und Onkologie"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41598-020-80302-4","article-title":"Anti\u2010Proliferative and Anti\u2010Migratory Properties of Coffee Diterpenes Kahweol Acetate and Cafestol in Human Renal Cancer Cells","volume":"11","author":"Makino T.","year":"2021","journal-title":"Scientific Reports"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141778","article-title":"Leishmanicidal Effect of Synthetic Trans\u2010Resveratrol Analogs","volume":"10","author":"Passos C. L. A.","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/bcr2889","article-title":"Choosing the Right Cell Line for Breast Cancer Research","volume":"13","author":"Holliday D. L.","year":"2011","journal-title":"Breast Cancer Research"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.foodchem.2018.03.111","article-title":"Lipase\u2010Catalysed Esters Synthesis of Cafestol and Kahweol","volume":"259","author":"Novaes F. J. M.","year":"2018","journal-title":"Food Chemistry"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4062\/biomolther.2014.133","article-title":"The Cytotoxicity of Kahweol in HT\u201029 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression","volume":"23","author":"Choi D. W.","year":"2015","journal-title":"Biomolecules & Therapeutics"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.3892\/ijo.2016.3727","article-title":"Kahweol Induces Apoptosis by Suppressing BTF3 Expression Through the ERK Signaling Pathway in Non\u2010Small Cell Lung Cancer Cells","volume":"49","author":"Jeon Y. J.","year":"2016","journal-title":"International Journal of Oncology"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.toxlet.2009.01.022","article-title":"Kahweol Blocks STAT3 Phosphorylation and Induces Apoptosis in Human Lung Adenocarcinoma A549 Cells","volume":"187","author":"Kim H. G.","year":"2009","journal-title":"Toxicology Letters"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.biopha.2017.05.109","article-title":"Cafestol, a Diterpene Molecule Found in Coffee, Induces Leukemia Cell Death","volume":"92","author":"Lima C. S.","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4062\/biomolther.2016.114","article-title":"Kahweol From Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells","volume":"25","author":"Park G. H.","year":"2017","journal-title":"Biomolecules & Therapeutics"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/PHARMACEUTICS15071796"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"83195","DOI":"10.18632\/oncotarget.20541","article-title":"The Coffee Diterpene Kahweol Enhances Sensitivity to Sorafenib in Human Renal Carcinoma Caki Cells Through Down\u2010Regulation of Mcl\u20101 and c\u2010FLIP Expression","volume":"8","author":"Min K. J.","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of Reactive Oxygen Species and NF\u2010\u03baB Signaling","volume":"21","author":"Morgan M. J.","year":"2011","journal-title":"Cell Research"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00432-013-1476-3","article-title":"Doxorubicin Induces Atypical NF\u2010\u03baB Activation Through c\u2010Abl Kinase Activity in Breast Cancer Cells","volume":"139","author":"Esparza\u2010L\u00f3pez J.","year":"2013","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-77750-3","article-title":"Identification of Potential TNF\u2010\u03b1 Inhibitors: From In Silico to In Vitro Studies","volume":"10","author":"Zia K.","year":"2020","journal-title":"Scientific Reports"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01818"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/genes9010024","article-title":"NF\u2010KappaB: Two Sides of the Same Coin","volume":"9","author":"Pires B.","year":"2018","journal-title":"Genes"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/pros.23753","article-title":"Coffee Diterpenes Kahweol Acetate and Cafestol Synergistically Inhibit the Proliferation and Migration of Prostate Cancer Cells","volume":"79","author":"Iwamoto H.","year":"2019","journal-title":"Prostate"},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1158\/1055-9965.EPI-15-0038-T","article-title":"Associations of Coffee Drinking With Systemic Immune and Inflammatory Markers","volume":"24","author":"Loftfield E.","year":"2015","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.617","article-title":"Metabolic Shifts During Coffee Consumption Refresh the Immune Response: Insight From Comprehensive Multiomics Analysis","volume":"5","author":"Ruan P.","year":"2024","journal-title":"MedComm (Beijing)"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3390\/nu10030363","article-title":"Effects of Coffee Extracts With Different Roasting Degrees on Antioxidant and Anti\u2010Inflammatory Systems in Mice","volume":"10","author":"Choi S.","year":"2018","journal-title":"Nutrients"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3390\/nu10070863","article-title":"Kahweol Ameliorates the Liver Inflammation Through the Inhibition of NF\u2010\u03baB and STAT3 Activation in Primary Kupffer Cells and Primary Hepatocytes","volume":"10","author":"Seo H. Y.","year":"2018","journal-title":"Nutrients"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/antiox11122345","article-title":"Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease","volume":"11","author":"Ngo V.","year":"2022","journal-title":"Antioxidants"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.foodchem.2018.03.111","article-title":"Lipase\u2010Catalysed Esters Synthesis of Cafestol and Kahweol","volume":"259","author":"Novaes F. J. M.","year":"2018","journal-title":"Food Chemistry"},{"key":"e_1_2_9_36_1","article-title":"Curcumin and Melphalan Cotreatment Induces Cell Cycle Arrest and Apoptosis in MDA\u2010MB\u2010231 Breast Cancer Cells","volume":"13","author":"Passos C. L. A.","year":"2023","journal-title":"Scientific Reports 2023 13:1"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies","volume":"58","author":"Chou T. C.","year":"2006","journal-title":"Pharmacological Reviews"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3390\/pharmaceutics16070873","article-title":"Oxyresveratrol in Breast Cancer Cells: Synergistic Effect With Chemotherapeutics Doxorubicin or Melphalan on Proliferation, Cell Cycle Arrest, and Cell Death","volume":"16","author":"Passos C. L. A.","year":"2024","journal-title":"Pharmaceutics"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s11033-020-05931-4","article-title":"5\u2010Aza\u20102\u2019\u2010deoxycytidine Induces a Greater Inflammatory Change, at the Molecular Levels, in Normoxic Than Hypoxic Tumor Microenvironment","volume":"48","author":"Salviano Soares de Amorim \u00cd.","year":"2021","journal-title":"Molecular Biology Reports"},{"issue":"1","key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"WebGestalt 2017: A More Comprehensive, Powerful, Flexible and Interactive Gene Set Enrichment Analysis Toolkit","volume":"45","author":"Wang J.","year":"2017","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz401"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/27.1.29","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","author":"Ogata H.","year":"1999","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1024"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1126\/science.1116304","article-title":"Small\u2010Molecule Inhibition of TNF\u2010\u03b1","volume":"310","author":"He M. M.","year":"2005","journal-title":"Science"},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"11140","DOI":"10.1002\/anie.201405820","article-title":"History of the Harvard ChemDraw Project","volume":"53","author":"Evans D. A.","year":"2014","journal-title":"Angewandte Chemie International Edition"},{"key":"e_1_2_9_46_1","first-page":"82","article-title":"Pymol: An Open\u2010Source Molecular Graphics Tool","volume":"40","author":"DeLano W. L.","year":"2002","journal-title":"CCP4 Newsletter on Protein Crystallography"},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and Interpreting Cancer Genomics Data via the Xena Platform","volume":"38","author":"Goldman M. J.","year":"2020","journal-title":"Nature Biotechnology"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database Hallmark Gene Set Collection","volume":"1","author":"Liberzon A.","year":"2015","journal-title":"Cell Systems"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1007\/s12013-024-01439-x","article-title":"STAT3 Regulates the Redox Profile in MDA\u2010MB\u2010231 Breast Cancer Cells","volume":"82","author":"Rodrigues J. A.","year":"2024","journal-title":"Cell Biochemistry and Biophysics"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.XINN.2024.100625"},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/bph.16257","article-title":"Transcriptome\u2010Level Discovery of Survival\u2010Associated Biomarkers and Therapy Targets in Non\u2010Small\u2010Cell Lung Cancer","volume":"181","author":"Gy\u0151rffy B.","year":"2024","journal-title":"British Journal of Pharmacology"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.70359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ardp.70359","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.70359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:59:54Z","timestamp":1791442794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.70359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ardp.70359"],"URL":"https:\/\/doi.org\/10.1002\/ardp.70359","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70359"}}