{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:40:42Z","timestamp":1792406442473,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>1,2,3\u2010Triazole and indole\u2010derived scaffolds are privileged nitrogen\u2010containing heterocyclic pharmacophores that form abundant non\u2010covalent interactions with tumor\u2010related biomacromolecules. Molecular hybridization that integrates these two scaffolds into a single molecular scaffold yields 1,2,3\u2010triazole\u2010indole\u2010derived hybrids, which can mitigate intrinsic drawbacks of single\u2010heterocycle anticancer small\u2010molecule agents, such as insufficient target selectivity, unsatisfactory pharmacokinetic performance, and acquired multidrug resistance. This review summarizes research advances on 1,2,3\u2010triazole\u2010indole\u2010derived anticancer hybrids published from 2021 to the present, and the structure\u2013activity relationships (SARs) as well as modes of action are discussed. These hybrids exert broad\u2010spectrum multi\u2010target anticancer effects through kinase inhibition, cell\u2010cycle arrest, caspase\u2010dependent apoptosis, anti\u2010angiogenic and anti\u2010migratory activities, tubulin polymerization disruption, as well as modulation of autophagy, immunogenic cell death, and the Janus kinase (JAK)\u2010signal transducer and activator of transcription (STAT) signaling axis. Representative candidates exhibit robust in vitro antiproliferative potency against diverse cancer cell lines, favorable selectivity toward normal human cells, satisfactory plasma metabolic stability, and potent in vivo tumor growth inhibitory effects. This comprehensive overview provides systematic theoretical guidance and rational design principles for further development and clinical translation of high\u2010efficiency, low\u2010toxicity 1,2,3\u2010triazole\u2010indole\u2010derived hybrid lead compounds for precise therapy against cancers.<\/jats:p>","DOI":"10.1002\/ardp.70363","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:47:12Z","timestamp":1792403232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["1,2,3\u2010Triazole\u2010Indole Derived Hybrids: Recent Progress and Therapeutic Perspectives for Cancer Treatment"],"prefix":"10.1002","volume":"359","author":[{"given":"Jialin","family":"Zhou","sequence":"first","affiliation":[{"name":"Wuhan Vocational College of Software and Engineering Wuhan Open University Wuhan China"},{"name":"Ministry of Education Collaborative Innovation Center for Drug Solubilization Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-1392","authenticated-orcid":false,"given":"Zhi","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine Guiyang Guizhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tourman.2025.105362","article-title":"Embracing Life While Confronting Mortality: Therapeutic Mechanisms of Travel for Cancer Patients","volume":"114","author":"Qiao G.","year":"2026","journal-title":"Tourism Management"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-024-01856-7","article-title":"Exploring Treatment Options in Cancer: Tumor Treatment Strategies","volume":"9","author":"Liu B.","year":"2024","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"9663","DOI":"10.1007\/s11033-023-08809-3","article-title":"Cancer Treatment Therapies: Traditional to Modern Approaches to Combat Cancers","volume":"50","author":"Kaur R.","year":"2023","journal-title":"Molecular Biology Reports"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41571-025-01059-1","article-title":"Understanding and Overcoming Multidrug Resistance in Cancer","volume":"22","author":"Ge M.","year":"2025","journal-title":"Nature Reviews Clinical Oncology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-023-01954-6","article-title":"Chemotherapy: How to Reduce Its Adverse Effects While Maintaining the Potency?","volume":"40","author":"Brianna A.","year":"2023","journal-title":"Medical Oncology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.3390\/ph15091071","article-title":"Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids","volume":"15","author":"Singh A. 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