{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T01:41:55Z","timestamp":1776044515720,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["arthroscopyjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the precision of patient\u2010specific instrumentation (PSI) in medial open wedge high tibial osteotomy (MOWHTO) based on medial proximal tibial angle (MPTA) and evaluate cartilage regeneration and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From August 2018 to December 2022, patients undergoing PSI\u2010guided MPTA\u2010based MOWHTO were included, with a minimum follow\u2010up period of 2 years. Exclusion criteria included MOWHTO without PSI, surgical planning not based on MPTA, bilateral knee surgery, procedure changes during surgery, and loss of follow\u2010up. Accuracy was classified into 3 categories: high, acceptable, and low accuracy based on the correction error (\u22641\u00b0, 1\u00b0\u20102\u00b0, and &gt;2\u00b0, respectively). Paired\u2010sample t\u2010tests compared preoperative and postoperative alignment and clinical scores, while rank sum and Fisher's exact tests assessed arthroscopic findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Radiological and clinical assessments were conducted on 39 patients. Cartilage regeneration was assessed by arthroscopy in 30 knees during implant removal. The error between preoperative planning and postoperative MPTA was at 0.1\u00b0\u2009\u00b1\u20091.7\u00b0 (95% CI: \u22120.5 to 0.6). The number of knees having the high, acceptable, and low accuracy was 21 (54%), 9 (23%), and 9 (23%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u2009.03) respectively. No significant changes were observed in posterior tibial slope. The KOOS showed a significant improvement after surgery compared to the preoperative score, from 47\u2009\u00b1\u200918 to 74\u2009\u00b1\u200914 with 100% patients exceeding the threshold for minimal clinically important difference. The mean weight\u2010bearing line percentage significantly improved 19.5%\u2009\u00b1\u200910.1% to 59.0%\u2009\u00b1\u20097.3%, and the mean MPTA was corrected from 84.7\u00b0\u2009\u00b1\u20091.8\u00b0 preoperatively to 92.6\u00b0\u2009\u00b1\u20092.1\u00b0 postoperatively. A second\u2010look arthroscopy revealed significant cartilage regeneration on the medial femoral condyle surfaces.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of PSI in MPTA\u2010based MOWHTO resulted in highly and acceptably accurate correction in the majority of cases, preservation of the PTS, and improved clinical outcomes in all patients. Furthermore, MOWHTO promotes cartilage regeneration at MFC following a 2\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV, retrospective study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/arj.70018","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:36:23Z","timestamp":1773156983000},"page":"219-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient\u2010Specific Instrumentation in Medial Proximal Tibial Angle\u2010Based Medial Open Wedge High Tibial Osteotomy: Improved Correction, Accuracy, and Cartilage Regeneration at Second\u2010Look Arthroscopy"],"prefix":"10.1002","volume":"42","author":[{"given":"Thanh Sang","family":"Nguyen","sequence":"first","affiliation":[{"name":"International Master\/Ph.D. Program in Medicine College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University  Taipei Taiwan"},{"name":"Hue Central Hospital  Hue Thua Thien Hue Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang Yuan","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Orthopedics School of Medicine College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Orthopedics Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Orthopedics Research Center Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Chun","family":"Wong","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University  Taipei 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