{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:22:36Z","timestamp":1791451356002,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":70,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":70,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["arthroscopyjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To perform a systematic review evaluating indications, preparation methods, and outcomes of randomized controlled trials (RCTs) involving platelet\u2010rich plasma (PRP) injections for extra\u2010articular hip pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature review was performed using the PubMed\u2010MEDLINE, Embase, and Cochrane databases. Only RCTs evaluating extra\u2010articular PRP hip injections were included. Study design, patient and disease characteristics, PRP processing methodology using the Platelet\u2010Activation\u2010White blood cell (PAW) classification, and patient\u2010reported outcomes were analyzed. Study quality was assessed by the revised Cochrane risk\u2010of\u2010bias tool for randomized trials (RoB2). Meta\u2010analyses were performed for studies evaluating the same pathology with comparable outcome metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven RCTs (581 hips) were included with a focus on hamstring (five studies, 4 acute muscular injury; 208 patients, 1 chronic proximal tendinopathy; 17 patients), greater trochanteric pain syndrome or abductor tendinopathy (five studies; 263 patients), and piriformis (one study; 60 patients) pathology. PRP yielded superior outcomes compared to control groups for at least one time point in three RCTs (60%) on gluteal tendinopathy and two RCTs (50%) evaluating return to sport rate following acute hamstring injury. Meta\u2010analyses found high heterogeneity (I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.92) in greater trochanteric pain syndrome (GTPS) studies with a significant treatment effect for the modified Harris Hip Score favoring PRP (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.005) compared to control groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.08). There was lower heterogeneity for hamstring studies (I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.65) and a significant treatment effect favoring PRP with an 8\u2010day shorter return to sport (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All RCTs found improvements in pain and function following PRP injection with clinically relevant outcome thresholds and meta\u2010analyses favoring PRP when treating GTPS and hamstring pathology. While there is substantial heterogeneity in study design, PRP formulations, control groups, outcome metrics, and follow\u2010up time, all reviewed RCTs showed comparable or superior outcomes with PRP compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level I, systematic review of Level I randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/arj.70024","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:07:11Z","timestamp":1773310031000},"page":"310-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved Outcomes With Platelet\u2010Rich Plasma for Treating Extra\u2010articular Hip Pathology Especially Greater Trochanteric Pain Syndrome and Hamstring Injury: A Systematic Review of Randomized Controlled Trials"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0593-481X","authenticated-orcid":false,"given":"Benjamin D.","family":"Kuhns","sequence":"first","affiliation":[{"name":"American Hip Institute Research Foundation  Chicago Illinois U.S.A."},{"name":"American Hip Institute  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-2096","authenticated-orcid":false,"given":"Nils","family":"Becker","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation  Chicago Illinois U.S.A."},{"name":"Department of Orthopedic Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9121-2870","authenticated-orcid":false,"given":"Absolon","family":"Reyes\u2010Cordova","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6918-3062","authenticated-orcid":false,"given":"Matthew J.","family":"Strok","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-5583","authenticated-orcid":false,"given":"Roger","family":"Quesada\u2010Jimenez","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8396-7099","authenticated-orcid":false,"given":"Ady H.","family":"Kahana\u2010Rojkind","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation  Chicago Illinois U.S.A."},{"name":"Department of Orthopedic Surgery ABC Medical Center  Mexico City Mexico"},{"name":"Ortomove  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-8647","authenticated-orcid":false,"given":"Benjamin G.","family":"Domb","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation  Chicago Illinois U.S.A."},{"name":"American Hip Institute  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-021-00235-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.9.831"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhps\/hnab028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.17.00024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-011-9239-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rap\/rkae022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-22-00397"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967116676241"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515620383"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhps\/hnab001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-023-07624-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05787-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhps\/hnaa044"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465221095563"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519826969"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520916729"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2018.345"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200507000-00002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.04.148"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/BMR-210032"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671241249123"},{"key":"e_1_2_8_26_1","first-page":"e6583","article-title":"Ultrasound\u2010guided platelet\u2010rich plasma application versus corticosteroid injections for the treatment of greater trochanteric pain syndrome: A prospective controlled randomized comparative clinical study","volume":"12","author":"Begkas D","year":"2020","journal-title":"Cureus."},{"key":"e_1_2_8_27_1","first-page":"22","article-title":"No attributable effects of PRP on greater trochanteric pain syndrome","volume":"132","author":"Thompson G","year":"2019","journal-title":"N Zealand M\u00e9d J."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/1413-785220162404159837"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.32098\/mltj.01.2019.20"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.8.1455"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2014-094250"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2015-094603"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514541540"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1402340"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10195-024-00791-1"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211064303"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515580787"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhps\/hny027"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.09.044"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-03175-5"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2022.09.020"},{"key":"e_1_2_8_42_1","first-page":"325","article-title":"Efficacy of botulinum toxin, local anesthetics, and corticosteroids in patients with piriformis syndrome: A systematic review and meta\u2010analysis","volume":"25","author":"Hilal FM","year":"2022","journal-title":"Pain Physician."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.14.12030"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.32098\/mltj.04.2014.11"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2018.08.001"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967120911731"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2017.06.039"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000003273"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-18-00305"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967113494354"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/arj.70024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/arj.70024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/arj.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:53:41Z","timestamp":1776041621000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1002\/arj.70024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/arj.70024"],"URL":"https:\/\/doi.org\/10.1002\/arj.70024","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}