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In vivo, rabbits with infraspinatus tendon detachment and repair were randomly assigned to control, LIPUS, MH, or combined treatment groups. Interventions were applied daily beginning shortly after surgery, and tendon\u2010bone healing was evaluated at defined postoperative intervals using histological, immunohistochemical, micro\u2010CT, and biomechanical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Optimal LIPUS and MH conditions significantly enhanced BMSC proliferation compared with other settings. Combined LIPUS and MH treatment further promoted BMSC proliferation, migration, and chondrogenic differentiation relative to either treatment alone. In vivo, the combined group showed the most organized collagen alignment, robust fibrocartilage regeneration, highest bone volume fraction, and significantly improved biomechanical strength at both time points (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). Micro\u2010CT and histological analyses confirmed superior osteochondral integration in the combined group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of LIPUS and MH significantly enhanced BMSCs proliferation, chondrogenic differentiation, and tendon\u2010bone healing in a rabbit rotator cuff repair model. Compared with single interventions, the combined treatment led to improved histological organization, increased COL\u2010II expression, and higher biomechanical strength at the tendon\u2010bone interface.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>The combination of LIPUS and MH significantly enhances tendon\u2010to\u2010bone healing in rotator cuff injuries, offering a promising non\u2010invasive therapeutic strategy for improving repair quality and functional recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/arj.70060","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:58:44Z","timestamp":1772989124000},"page":"853-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low\u2010Intensity Pulsed Ultrasound Combined With Mild Hyperthermia 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