{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:20:03Z","timestamp":1790475603449,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["arthroscopyjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the impact of preoperative glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101 RA) use on medical complications, emergency department use, and orthopaedic complications in obese patients undergoing arthroscopic rotator cuff repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Obese patients (defined by relevant ICD\u201010 codes and confirmed by body mass index measurements) undergoing primary arthroscopic rotator cuff repair before June 2023 with at least 2\u2010year follow\u2010up were found in the TriNetX database and stratified according to GLP\u20101 RA use before surgery. Patients prescribed GLP\u20101 RAs were propensity\u2010matched 1:1 to non\u2010GLP\u20101 RAs controls by age, sex, ethnicity, and comorbidities. Outcomes assessed included emergency department use\u00a0at 30 and 90\u2009days, medical complications assessed at 90\u2009days, and orthopaedic complications (including revision, retear, and conversion to arthroplasty rates, defined by ICD\u201010 codes) assessed at 1 and 2\u2009years postoperatively. Statistical analysis was performed using TriNetX's built\u2010in statistical platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following matching, both cohorts consisted of 1183 patients and had no baseline differences. At 90\u2009days, there were no significant differences in medical complications, including acute kidney injury, pneumonia, venous thromboembolism, urinary tract infection, or cardiac events. At 1 and 2\u2009years, GLP\u20101 RA use was associated with significantly lower revision rates after left\u2010sided repairs (2.3% vs 7.2%, OR 0.3,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001; 4.0% vs 8.2%, OR 0.5,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.010, respectively). In subgroup analyses, women undergoing left\u2010sided repairs showed significantly lower retear rates at both 1 and 2\u2009years (19.1% vs 30.9%, OR 0.5,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.009; 20.2% vs 33.5%, OR 0.5,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RAs appear to be generally safe for preoperative use in obese patients undergoing arthroscopic rotator cuff repair and were associated with decreased rates of revision and retear in certain subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III, retrospective comparative case series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/arj.70370","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:44:46Z","timestamp":1781811886000},"page":"1958-1968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glucagon\u2010Like Peptide\u20101 Receptor Agonist Use in Obese Patients Is Associated With Decreased Risk of Revision and Retears After Arthroscopic Rotator Cuff Repair"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9718-3803","authenticated-orcid":false,"given":"Argen","family":"Omurzakov","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsen M.","family":"Omurzakov","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Burkhart","sequence":"additional","affiliation":[{"name":"UH Drusinsky Sports Medicine Institute  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Voos","sequence":"additional","affiliation":[{"name":"UH Drusinsky Sports Medicine Institute  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4895-1046","authenticated-orcid":false,"given":"Jacob G.","family":"Calcei","sequence":"additional","affiliation":[{"name":"UH Drusinsky Sports Medicine Institute  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1615-6192","authenticated-orcid":false,"given":"John M.","family":"Apostolakos","sequence":"additional","affiliation":[{"name":"UH Drusinsky Sports Medicine Institute  Cleveland Ohio 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