{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:05:14Z","timestamp":1789275914250,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["arthroscopyjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the efficacy of injected leukocyte\u2010poor platelet\u2010rich plasma (LP\u2010PRP) during arthroscopic rotator cuff repair, primarily in reducing failure rates and, secondarily, in improving shoulder function and clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta\u2010Analysis guidelines. Medline\/PubMed, Scopus, Web of Science, and Cochrane databases were searched up to August 31, 2025, for comparative studies investigating the injectable LP\u2010PRP during arthroscopic rotator cuff repair. Inclusion criteria were Level I or II studies reporting clinical and radiological outcomes with more than 6\u2010month follow\u2010up. Data were extracted on failure incidence and patient\u2010reported outcome measures. Quantitative synthesis was performed using inverse variance weighting, and heterogeneity was assessed with the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five randomized controlled trials (n\u2009=\u2009470 patients; 235 LP\u2010PRP, 235 control) were included. No difference was found in mean age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.760) and gender distribution (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009&gt;.99) between the 2 study groups. Repair failure occurred in 34\/213 (15.9%) in the LP\u2010PRP group versus 63\/217 (29.0%) in controls (odds ratio 2.16; 95% confidence interval 1.34\u20103.48;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001; relative risk 0.55; 95% confidence interval 0.38\u20100.79). The LP\u2010PRP group showed greater improvements in Constant score at 6\u2009months (31.6 vs 28.4;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001), 12\u2009months (46.9 vs 44.2;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001), and 24\u2009months (45.7 vs 42.8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.003), Single Assessment Numeric Evaluation at 12\u2009months (42 vs 38.7;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.036), University of California\u2010Los Angeles at 6, 12, and 24\u2009months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001 for all), and visual analog scale at 3\u2009months (5.9 vs 4.6;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001) and 24\u2009months (5.2 vs 4.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.012); nevertheless, none of these improvements reached the minimal clinically important difference. Complication rates were comparable between groups (9.4% vs 7.7%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.508).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Injection of LP\u2010PRP during rotator cuff repair appears to be a safe procedure that may increase the healing rate. However, it has not been associated with improvements in patient\u2010reported outcome measures sufficient to reach the minimal clinically important difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, systematic review of Level I and II randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/arj.70537","type":"journal-article","created":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:25:03Z","timestamp":1789273503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Injection of Leukocyte\u2010Poor Platelet\u2010Rich Plasma During Rotator Cuff Repair Can Increase Healing Rate but Does Not Affect Clinical Outcomes: A Systematic Review and Meta\u2010analysis of Randomized Controlled Trials"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-866X","authenticated-orcid":false,"given":"Charalampos","family":"Pitsilos","sequence":"first","affiliation":[{"name":"Academic Department of Trauma and Orthopaedics School of Medicine University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2271-3550","authenticated-orcid":false,"given":"Dimitrios","family":"Rigkos","sequence":"additional","affiliation":[{"name":"1st Orthopaedic Department Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-2734","authenticated-orcid":false,"given":"Byron","family":"Chalidis","sequence":"additional","affiliation":[{"name":"1st Orthopaedic Department Aristotle University of Thessaloniki  Thessaloniki 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