{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:02:34Z","timestamp":1789581754543,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2022\u20102Z\u201040913"],"award-info":[{"award-number":["2022\u20102Z\u201040913"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["arthroscopyjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"abstract":"\n Purpose<\/jats:title>\n To evaluate the long\u2010term effect of age on clinical and radiological outcomes after bone marrow stimulation (BMS) for osteochondral lesions of the talus with \u226510\u2010year follow\u2010up and to identify prognostic factors in older patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients undergoing BMS for symptomatic, magnetic resonance imaging\u2010confirmed osteochondral lesions of the talus (lesion size <150\u2009mm\n 2<\/jats:sup>\n ) between 2009 and 2015 with a minimum 10\u2010year follow\u2010up were included and stratified into 3 age groups (<30, 30\u201045, and >45\u2009years). Clinical outcomes were assessed using the Foot and Ankle Outcome Score, American Orthopaedic Foot & Ankle Society score, Tegner activity scale, and visual analog scale. Cartilage repair was assessed with Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) and MOCART 2.0 scores on magnetic resonance imaging.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 103 patients were included. At a minimum 10\u2010year follow\u2010up (mean, 11.8\u2009years; range, 10.2\u201015.1), all groups showed significant improvements in pain, function, quality of life (QoL), and magnetic resonance imaging\u2010assessed cartilage repair compared with baseline. Patients <30\u2009years achieved the best outcomes (Foot and Ankle Outcome Score\u2010QoL 91.0 [85.0, 91.0], American Orthopaedic Foot & Ankle Society 92.0 [86.0, 96.0], and Tegner 6.0 [4.8, 6.3]), followed by those aged 30 to 45 and >45\u2009years (all\n P\u2009<\/jats:italic>\n <\u2009.001). American Orthopaedic Foot & Ankle Society minimal clinically important difference was achieved in 96.7%, 81.1%, and 72.2%, respectively (\n P<\/jats:italic>\n \u2009=\u2009.032), and QoL minimal clinically important difference was achieved in 96.7%, 70.3%, and 52.8%, respectively (\n P\u2009<\/jats:italic>\n <\u2009.001). MOCART and MOCART 2.0 scores were significantly higher in patients <45\u2009years than in those >45\u2009years (\n P\u2009<\/jats:italic>\n =\u2009.031 and .035). In patients >45\u2009years, symptom duration >25.5\u2009months (area under the curve\u2009=\u20090.788; sensitivity, 82.4%; specificity, 78.9%) and baseline bone marrow edema depth >10.5\u2009mm (area under the curve\u2009=\u20090.772; sensitivity, 70.6%; specificity, 84.2%) were thresholds predictive of failure to achieve QoL minimal clinically important difference.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Age may negatively influence the long\u2010term outcomes of BMS for osteochondral lesions of the talus. In patients >45\u2009years, a preoperative symptom duration longer than 25.5\u2009months and baseline bone marrow edema depth greater than 10.5\u2009mm were associated with unfavorable outcomes after BMS.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n Level III, retrospective comparative study.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/arj.70562","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:16:18Z","timestamp":1789578978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age Greater Than 45, Preop Symptom Duration, and Bone Marrow Edema Depth Negatively Impact Long\u2010Term Outcomes After Bone Marrow Stimulation for Osteochondral Lesions of the Talus"],"prefix":"10.1002","author":[{"given":"Lei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Sports Medicine Peking University Third Hospital Beijing China"},{"name":"Beijing Key Laboratory of Research and Translation for Drugs and Medical Devices in Precision Diagnosis and Treatment of Sports Injuries Institute of Sports Medicine of Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Peking University Third Hospital Beijing China"},{"name":"Beijing Key Laboratory of Research and Translation for Drugs and Medical Devices in Precision Diagnosis and Treatment of Sports Injuries Institute of Sports Medicine of Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Peking University Third Hospital Beijing China"},{"name":"Beijing Key Laboratory of Research and Translation for Drugs and Medical Devices in Precision Diagnosis and Treatment of Sports Injuries Institute of Sports Medicine of Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyue","family":"Pei","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Epidemiology Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Epidemiology Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Peking University Third Hospital Beijing China"},{"name":"Beijing Key Laboratory of Research and Translation for Drugs and Medical Devices in Precision Diagnosis and Treatment of Sports Injuries Institute of Sports Medicine of Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Peking University Third Hospital Beijing China"},{"name":"Beijing Key Laboratory of Research and Translation for Drugs and Medical Devices in Precision Diagnosis and Treatment of Sports Injuries Institute of Sports Medicine of Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The 951st Hospital of the People's Liberation Army Korla China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Peking University Third Hospital Beijing China"},{"name":"Beijing Key Laboratory of Research and Translation for Drugs and Medical Devices in Precision Diagnosis and Treatment of Sports Injuries Institute of Sports Medicine of Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4380-7683","authenticated-orcid":false,"given":"Dong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Peking University Third Hospital Beijing China"},{"name":"Beijing Key Laboratory of Research and Translation for Drugs and Medical Devices in Precision Diagnosis and Treatment of Sports Injuries Institute of Sports Medicine of Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.5312\/wjo.v11.i12.534","article-title":"Acute ankle sprain in athletes: Clinical aspects and algorithmic approach","volume":"11","author":"Halabchi F","year":"2020","journal-title":"World J 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talus","volume":"32","author":"Li YB","year":"2024","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1177\/10711007241250007","article-title":"Effect of cigarette smoking on postoperative outcomes after arthroscopic bone marrow stimulation for osteochondral lesions of the talus","volume":"45","author":"Cheng X","year":"2024","journal-title":"Foot Ankle Int."},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.arthro.2024.05.011","article-title":"Medial cystic osteochondral lesions of the talus exhibited lower sports levels, higher cyst presence rate, and inferior radiological outcomes compared with lateral lesions following arthroscopic bone marrow stimulation","volume":"41","author":"Cheng X","year":"2025","journal-title":"Arthroscopy."},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1177\/0363546516668292","article-title":"Lesion size is a predictor of clinical outcomes after bone marrow stimulation for osteochondral lesions of the talus: A systematic review","volume":"45","author":"Ramponi L","year":"2017","journal-title":"Am J Sports Med."},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/0363546511423739","article-title":"Osteochondral lesion of the talus: Could age be an indication for arthroscopic treatment?","volume":"40","author":"Choi WJ","year":"2012","journal-title":"Am J Sports Med."},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00402-025-05770-7","article-title":"No influence of patient age on operative treatment outcome of osteochondral lesions of the talus: Data from the German Cartilage Registry (GCR, KnorpelRegister 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