{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:00:52Z","timestamp":1789891252688,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["arthroscopyjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To systematically review the clinical, radiographic, and patient\u2010reported outcomes of osteochondral allograft (OCA) transplantation with versus without bone marrow aspirate (BMA) augmentation for the treatment of knee cartilage defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search was performed according to the 2020 Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. Comparative clinical studies assessing OCA with and without BMA were included. Two reviewers independently performed screening, data extraction, and methodological quality assessment using the Cochrane Risk of Bias Tool 2.0 for randomized trials and the Methodological Index for Non\u2010Randomized Studies for nonrandomized studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four studies (3 Level III, 1 Level I) involving 165 knees met the inclusion criteria. The mean follow\u2010up duration across studies ranged from 5.5 to 18.0\u2009months. Across 2 comparative studies, BMA augmentation was associated with fewer reoperations (2.4% vs 21.9%) compared with non\u2010BMA augmentation. Radiographic findings were heterogeneous: 1 study showed earlier integration and reduced sclerosis with BMA at 6\u2009months, whereas 2 magnetic resonance imaging\u2010based studies showed no differences in OCA Magnetic Resonance Imaging Scoring System scores. Computed tomography assessment in 1 trial found increased small cysts but a trend toward fewer large cysts in BMA\u2010treated grafts. Patient\u2010reported outcomes from 1 study showed no significant differences in International Knee Documentation Committee or Knee injury and Osteoarthritis Outcome Score for Joint Replacement scores between groups, although achievement of the Knee injury and Osteoarthritis Outcome Score for Joint Replacement minimal clinically important difference favored the BMA cohort (88% vs 55%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.076).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OCA transplantation augmented with BMA is associated with significantly lower reoperation rates compared with nonaugmented transplantation. Although short\u2010term radiographic data show improved early subchondral remodeling, these findings are not consistently corroborated by magnetic resonance imaging\u2010based scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III, systematic review of Level I and III studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/arj.70628","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:19:46Z","timestamp":1789888786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bone Marrow Aspirate Augmentation Reduces Reoperation Rates After Osteochondral Allograft Transplantation of the Knee: A Systematic Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-3222","authenticated-orcid":false,"given":"Napatpong","family":"Thamrongskulsiri","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Rush University Medical Center  Chicago Illinois U.S.A."},{"name":"Midwest Orthopaedics at Rush  Chicago Illinois U.S.A."},{"name":"Sports Medicine Research Group, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3734-6584","authenticated-orcid":false,"given":"Jacob T.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Rush University Medical Center  Chicago Illinois U.S.A."},{"name":"Midwest Orthopaedics at Rush  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Casanova","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Rush University Medical Center  Chicago Illinois U.S.A."},{"name":"Midwest Orthopaedics at Rush  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan D.","family":"Moews","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Rush University Medical Center  Chicago Illinois U.S.A."},{"name":"Midwest Orthopaedics at Rush  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B.","family":"Yanke","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Rush University Medical Center  Chicago Illinois U.S.A."},{"name":"Midwest Orthopaedics at Rush  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Rush University Medical Center  Chicago Illinois U.S.A."},{"name":"Midwest Orthopaedics at Rush  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-1150","authenticated-orcid":false,"given":"Jorge","family":"Chahla","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Rush University Medical Center  Chicago Illinois U.S.A."},{"name":"Midwest Orthopaedics at Rush  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.csm.2024.12.002","article-title":"Osteochondral allograft transplantation.","volume":"44","author":"Wang T","year":"2025","journal-title":"Clin Sports Med."},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/0363546520980087","article-title":"Osteochondral allograft transplant for focal cartilage defects of the femoral condyles: Clinically 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allograft transplantation of the knee: A systematic review and exploratory meta\u2010analysis","volume":"51","author":"Kunze KN","year":"2023","journal-title":"Am J Sports Med."},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1002\/ksa.70397","article-title":"Clinical improvement but substantial arthroplasty risk following fresh osteochondral allograft transplantation of the femoral head: A systematic review and single\u2010arm meta\u2010analysis","volume":"34","author":"Thamrongskulsiri N","year":"2026","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1055\/s-0037-1603800","article-title":"Bone marrow aspirate concentrate versus platelet rich plasma to enhance osseous integration potential for osteochondral allografts","volume":"31","author":"Stoker AM","year":"2018","journal-title":"J Knee 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femoral condylar osteochondral allografts","volume":"45","author":"Oladeji LO","year":"2017","journal-title":"Am J Sports Med."},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1016\/j.arthro.2019.03.033","article-title":"Effect of autogenous bone marrow aspirate treatment on magnetic resonance imaging integration of osteochondral allografts in the knee: A matched comparative imaging analysis","volume":"35","author":"Ackermann J","year":"2019","journal-title":"Arthroscopy."},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0363546518813915","article-title":"Bone marrow aspirate concentrate does not improve osseous integration of osteochondral allografts for the treatment of chondral defects in the knee at 6 and 12\u2009months: A comparative magnetic resonance imaging analysis","volume":"47","author":"Wang D","year":"2019","journal-title":"Am J Sports 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