{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:53:23Z","timestamp":1791215603508,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["arthroscopyjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy, Sports Medicine, and Rehabil."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the clinical and radiological effectiveness of porcine\u2010derived type I collagen injections in patients with symptomatic rotator cuff tendinopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this monocentric pilot study conducted between 2022 and 2025, adults with clinically and radiologically confirmed rotator cuff tendinopathy received 3 ultrasound\u2010guided intratendinous injections at 2\u2010week intervals and were followed for 12\u2009months. A power analysis determined that 24 patients were required to detect a 13\u2010point improvement in the Constant\u2010Murley Score (CMS) at 3\u2009months. The primary outcome was the achievement of a \u226513\u2010point increase in the CMS at 3\u2009months. Secondary outcomes included functional scores, pain intensity, magnetic resonance imaging findings, and analgesic consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four patients were enrolled, and 22 completed 12\u2010month follow\u2010up. At 3\u2009months, 8 out of 23 patients (35%) achieved the predefined 13\u2010point CMS as minimal clinically important difference. Mean CMS improved from 62.4 at baseline to 72.2 at 3\u2009months and 78.7 at 12\u2009months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). The American Shoulder and Elbow Surgeons score improved from 47.3 at baseline to 68.5 at 3\u2009months and 82.2 at 12\u2009months. The Simple Shoulder Test improved from 8.8 to 9.7 at 3\u2009months and 11.3 at 12\u2009months. Pain scores decreased from 5.8 at baseline to 3.5 at 3\u2009months and 2.1 at 12\u2009months. Magnetic resonance imaging at 12\u2009months showed improved tendon quality in 7 out of 20 evaluated patients (35%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intratendinous porcine\u2010derived type I collagen injections were associated with progressive improvements in shoulder function and pain over 12\u2009months in this single\u2010arm pilot study. Although the predefined minimal clinically important difference at 3\u2009months was reached by a proportion of patients, functional scores showed continued improvement throughout follow\u2010up. Magnetic resonance imaging findings showed improved tendon quality in part of the cohort, and no serious adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV, prospective therapeutic case series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ars2.70114","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:15:41Z","timestamp":1791213341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intratendinous Porcine\u2010Derived Type I Collagen Injections Result in Clinical and Radiographic Improvement of Rotator Cuff Tendinopathy 1 Year After Treatment"],"prefix":"10.1002","author":[{"given":"Pietro Simone","family":"Randelli","sequence":"first","affiliation":[{"name":"Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"U.O.C. 1\u00b0 Clinica Ortopedica ASST G. Pini\u2010CTO  Milan Italy"},{"name":"Research Center for Adult and Pediatric Rheumatic Diseases (RECAP\u2010RD), Department of Biomedical Sciences for Health Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Muzio","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"U.O.C. Week Surgery ASST Gaetano Pini\u2010CTO  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-7100","authenticated-orcid":false,"given":"Carlo","family":"Stoppani","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"U.O.C. 1\u00b0 Clinica Ortopedica ASST G. Pini\u2010CTO  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-3526","authenticated-orcid":false,"given":"Chiara","family":"Fossati","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"U.O.C. 1\u00b0 Clinica Ortopedica ASST G. Pini\u2010CTO  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Battista","family":"Gallazzi","sequence":"additional","affiliation":[{"name":"Department of Radiology ASST Gaetano Pini\u2010CTO  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Menon","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"U.O.C. 1\u00b0 Clinica Ortopedica ASST G. 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