{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:39:20Z","timestamp":1784176760748,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,2,5]],"date-time":"2002-02-05T00:00:00Z","timestamp":1012867200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[2002,2]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To study the role of biomechanical factors and HLA\u2010B27 in plantar fasciitis.<\/jats:p><\/jats:sec>Methods<\/jats:title>T1\u2010weighted and T2 spectral presaturation with inversion recovery (fat suppressed) magnetic resonance imaging (MRI) sequences of the plantar fascia insertion and adjacent bone were performed on 28 patients with plantar fasciitis; 17 had spondylarthropathy (SpA)\u2010associated disease, and 11 had mechanically induced disease. The relationship between the degree of bone edema, scored on a semiquantitative scale (from absent to severe), and the patient's HLA\u2010B27 status was determined.<\/jats:p><\/jats:sec>Results<\/jats:title>On MRI, edema within the soft tissue at the enthesis was evident in both groups. Bone edema in the adjacent calcaneum was evident in 64.7% (11 of 17) of patients with SpA and in 45% (5 of 11) of those with mechanically induced disease (P<\/jats:italic> = 0.441). HLA\u2010B27 was identified in 9 (53%) of the patients with SpA but in none (0%) of those with mechanically induced disease. All 6 of the SpA patients with extensive bone edema but none of the 5 SpA patients with mild bone edema were HLA\u2010B27 positive (P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The association of HLA\u2010B27 with bone pathology in early enthesitis may have implications for a better understanding of the pathogenesis of SpA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10125","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:20:15Z","timestamp":1030314015000},"page":"489-493","source":"Crossref","is-referenced-by-count":171,"title":["The role of biomechanical factors and HLA\u2010B27 in magnetic resonance imaging\u2010determined bone changes in plantar fascia enthesopathy"],"prefix":"10.1002","volume":"46","author":[{"given":"Dennis","family":"McGonagle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Marzo\u2010Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Gibbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Pease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Reece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Emery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,2,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.3.213"},{"key":"e_1_2_6_3_2","first-page":"681","volume-title":"Oxford Textbook of Rheumatology","author":"Calin A","year":"1993"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199907000-00004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199804)41:4<694::AID-ART17>3.0.CO;2-#"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.2.135"},{"key":"e_1_2_6_7_2","first-page":"2295","article-title":"Ankylosing spondylitis\u2014at the interface of bone and cartilage","volume":"27","author":"Maksymowych WP","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_2","first-page":"2302","article-title":"Enthesitis, osteitis, microbes, biomechanics and immune reactivity in ankylosing spondylitis","volume":"27","author":"McGonagle D","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341003"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7441.702"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100130414"},{"key":"e_1_2_6_12_2","first-page":"2155","article-title":"An enthesitis based disease model for spondyloarthropathy","volume":"28","author":"McGonagle D","year":"2001","journal-title":"J Rheumatol"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.10125","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.10125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T01:05:59Z","timestamp":1698714359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.10125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1002\/art.10125"],"URL":"https:\/\/doi.org\/10.1002\/art.10125","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}