{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:01Z","timestamp":1790741941917,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,5]],"date-time":"2002-04-05T00:00:00Z","timestamp":1017964800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To address the hypothesis that endothelial cells and\/or muscle fibers are primary targets in the disease process by analysis of muscle tissue from patients with polymyositis (PM) and dermatomyositis (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients with laboratory signs and clinical symptoms typical of myositis, but without detectable infiltration of clusters of inflammatory cells in their muscle biopsy samples. An immunohistochemical technique was applied to identify CD3, CD68, lymphocyte function\u2013associated antigen 1\u03b1, CD11b, very late activation antigen 4, endothelium 4, interleukin\u20101\u03b1 (IL\u20101\u03b1), intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IgG, IgM, IgA, and HLA\u2013A\/B\/C in muscle tissue. Fiber type was defined by ATPase staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u20101\u03b1 expression was detected in endothelial cells of capillaries to a greater extent in patients than in controls, and class I major histocompatibility complex (MHC) expression was significantly increased in muscle fibers. We also observed that class I MHC expression was mainly confined to type II muscle fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings imply that defined molecular changes of blood vessels and muscle fibers are both independent of adjacent inflammatory infiltrates and could thus be primary events in the development of myositis. Moreover, both IL\u20101\u03b1 and class I MHC molecules might be important for the development of clinical symptoms in PM and DM patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10140","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:44:07Z","timestamp":1030319047000},"page":"1044-1055","source":"Crossref","is-referenced-by-count":77,"title":["Interleukin\u20101\u03b1 expression in capillaries and major histocompatibility complex class I expression in type II muscle fibers from polymyositis and dermatomyositis patients: Important pathogenic features independent of inflammatory cell clusters in muscle tissue"],"prefix":"10.1002","volume":"46","author":[{"given":"Pernilla","family":"Englund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Nennesmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Klareskog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E.","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370709"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160206"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790100308"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-2-143"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400514"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199811000-00004"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)43:2<336::AID-ANR13>3.0.CO;2-V"},{"key":"e_1_2_6_9_2","first-page":"185","article-title":"Expression of cell adhesion molecules in inflammatory myopathies","volume":"59","author":"Tews DS","year":"1995","journal-title":"J Neurol"},{"key":"e_1_2_6_10_2","first-page":"467","article-title":"Leucocyte\/endothelial cell adhesion receptors in muscle biopsies from patients with idiopathic inflammatory myopathies (IIM)","volume":"104","author":"Cid MC","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199407000-00008"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270402"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90400-W"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90228-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06032.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230111"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91384-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90128-7"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200003)23:3<385::AID-MUS10>3.0.CO;2-T"},{"key":"e_1_2_6_20_2","first-page":"940","article-title":"Increased expression of interleukin\u20101 alpha and MHC class I in muscle tissue of patients with chronic, inactive polymyositis and dermatomyositis","volume":"27","author":"Nyberg P","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"e_1_2_6_23_2","first-page":"328","article-title":"Comparison between 3 diagnostic criteria for mixed connective tissue disease: study of 593 patients","volume":"16","author":"\u00c1lar\u00e7on\u2010Segovid D","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1979.tb02942.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00011-8"},{"key":"e_1_2_6_28_2","first-page":"261","volume-title":"Disorders of voluntary muscle","author":"Sewry CA","year":"1994"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749309095142"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1990.tb04081.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090510"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.8.493"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.8.1592209"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)81662-3"},{"key":"e_1_2_6_35_2","volume-title":"Immunobiology: the immune system in health and disease","author":"Janeway CA","year":"1996"},{"issue":"2","key":"e_1_2_6_36_2","first-page":"A132","article-title":"Interleukin\u20101 is toxic to human muscle","volume":"44","author":"Leon\u2010Monzon M","year":"1994","journal-title":"Neurology"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1997.tb01195.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199603000-00009"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199711000-00008"},{"key":"e_1_2_6_40_2","first-page":"R621","article-title":"Regulation of insulin\u2010like growth factor (IGF)\u2010I mRNA and peptide and IGF\u2010binding proteins by interleukin\u20101","volume":"270","author":"Fan J","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199904000-00002"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1998.18.879"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9209"},{"key":"e_1_2_6_44_2","volume-title":"Diseases of skeletal muscle","author":"Wortmann RL","year":"2000"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<631::AID-ANR5>3.0.CO;2-X"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118377"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197202172860701"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.10140","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.10140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T01:04:52Z","timestamp":1700701492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.10140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1002\/art.10140"],"URL":"https:\/\/doi.org\/10.1002\/art.10140","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}