{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:03:53Z","timestamp":1792782233348,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,5,8]],"date-time":"2002-05-08T00:00:00Z","timestamp":1020816000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001729","name":"Swedish Foundation for Strategic Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Society for Medicine"},{"name":"Magn. Bergvall Foundation"},{"name":"Prof. Nanna Svartz' Foundation"},{"name":"King Gustav V's 80-year Foundation"},{"name":"Swedish Rheumatism Association (Karolinska Institutet)","id":[{"id":"https:\/\/ror.org\/00zps9v98","id-type":"ROR","asserted-by":"crossref"}]},{"name":"\u00c5ke Winberg Foundation"},{"name":"Groschinsky Foundation"},{"DOI":"10.13039\/501100009747","name":"Erik and Edith Fernstr\u00f6m Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009747","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009745","name":"Emil and Wera Cornell Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009745","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jeansson Foundation","id":[{"id":"https:\/\/ror.org\/00r6p8t42","id-type":"ROR","asserted-by":"crossref"}]},{"name":"B\u00f6rje Dahlin Foundation (Karolinska Institutet)","id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Do491\/4-3)"],"award-info":[{"award-number":["Do491\/4-3)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the humoral immune response to Ro\/SSA and La\/SSB antigens in detail, in order to identify markers in mothers at high risk of having children with congenital heart block (CHB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples were obtained from 9 Ro\/La\u2010positive mothers who gave birth to affected children, from their 8 newborns with CHB, and from 26 Ro\/La\u2010positive mothers whose children were healthy. Antibodies against Ro 52\u2010kd, Ro 60\u2010kd, and La were analyzed by enzyme\u2010linked immunosorbent assay and immunoblotting, using recombinant proteins and synthetic peptides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IgG anti\u2010Ro 52\u2010kd antibodies were detected in all mothers who gave birth to children with CHB, as well as in their affected children, but were less frequent and at lower levels in control mothers. Fine mapping revealed a striking difference in which the response in mothers with affected children was dominated by antibodies to amino acids 200\u2013239 of the Ro 52\u2010kd protein (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0002), whereas the primary activity in control mothers was against amino acids 176\u2013196 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001). Furthermore, 8 of 9 mothers of children with CHB had antibody reactivity against amino acids 1\u2013135 of the Ro 52\u2010kd protein, containing 2 putative zinc fingers reconstituted under reducing conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results suggest that development of CHB is strongly dependent on a specific antibody profile to Ro 52\u2010kd, which may be a useful tool to identify pregnant Ro\/La\u2010positive women at risk of delivering a baby with CHB. Close monitoring of mothers at high risk would enable early detection of a block that is still developing and allow early treatment to combat more serious complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.10232","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T08:20:06Z","timestamp":1033892406000},"page":"1233-1241","source":"Crossref","is-referenced-by-count":135,"title":["A serologic marker for fetal risk of congenital heart 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