{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:09:49Z","timestamp":1791328189887,"version":"4.3.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2002,7,11]],"date-time":"2002-07-11T00:00:00Z","timestamp":1026345600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if the prevalence of autoimmunity among relatives of patients with juvenile rheumatoid arthritis (JRA) is greater than that among relatives of healthy volunteer control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Interviews were used to obtain histories of the following disorders among living first\u2010 and second\u2010degree relatives of 110 patients and 45 controls: alopecia areata, ankylosing spondylitis, dermatomyositis, Graves' disease, Hashimoto thyroiditis, insulin\u2010dependent diabetes mellitus, inflammatory bowel disease, iritis, JRA, multiple sclerosis, psoriasis, RA, systemic lupus erythematosus, and vitiligo. Chi\u2010squares, odds ratios (ORs), and 95% confidence intervals (95% CIs) were calculated. Families of 23 JRA affected sibpairs were interviewed subsequently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between patients and controls with regard to age, sex, ethnicity, or family size. Patients had 1,228 relatives and controls had 496 relatives. Of all the relatives of the patients, 155 had at least 1 autoimmune disorder, compared with 20 relatives of the controls (12.6% versus 4.0%; OR 3.4 [95% CI 2.1\u20135.7], <jats:italic>P<\/jats:italic> &lt; 0.000001). The prevalence of autoimmunity was increased in first\u2010degree and in second\u2010degree relatives of patients (16.1% and 10.6%, respectively). The prevalence of Hashimoto thyroiditis was significantly higher in the relatives of patients (OR 3.5 [95% CI 1.6\u20137.9], <jats:italic>P<\/jats:italic> = 0.0008). The prevalences of other disorders were not significantly different. JRA affected sibpair families had an increased prevalence of autoimmunity (15.0%). A history of arthritis was found significantly more frequently in the JRA affected sibpair families, but not in the simplex families.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data demonstrate that the prevalence of autoimmunity is significantly higher among first\u2010 and second\u2010degree relatives of JRA patients. This suggests that clinically different autoimmune phenotypes may share common susceptibility genes, which may act as risk factors for autoimmunity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10370","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T02:05:28Z","timestamp":1031709928000},"page":"1851-1856","source":"Crossref","is-referenced-by-count":120,"title":["Increased prevalence of familial autoimmunity in simplex and multiplex families with juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"46","author":[{"given":"Sampath","family":"Prahalad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith S.","family":"Shear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward H.","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.9979"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4412"},{"key":"e_1_2_6_4_2","first-page":"598","article-title":"Primary ovarian failure, juvenile rheumatoid arthritis, and vitiligo","volume":"133","author":"Collen RJ","year":"1979","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_5_2","first-page":"93","article-title":"Diabetes mellitus, Hashimoto's thyroiditis, and juvenile rheumatoid arthritis","volume":"134","author":"Fisher M","year":"1980","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_6_2","first-page":"37","article-title":"Familial aggregation and twin studies in Still's disease: juvenile chronic polyarthritis","volume":"2","author":"Ansell BM","year":"1969","journal-title":"Rheumatology"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(82)90034-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401107"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200010)43:10<2335::AID-ANR22>3.0.CO;2-W"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2611::AID-ANR33>3.0.CO;2-T"},{"issue":"4","key":"e_1_2_6_11_2","first-page":"S85","article-title":"Familial prevalence of immunologically\u2010mediated diseases (IMD) in juvenile rheumatoid arthritis (JRA)","volume":"26","author":"Church JL","year":"1983","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400822"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199803)41:3<400::AID-ART4>3.0.CO;2-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050853"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.101001036.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/32.1.36"},{"issue":"1","key":"e_1_2_6_18_2","first-page":"97","article-title":"Molecular epidemiology of autoimmune thyroid disease","volume":"133","author":"Dorman J","year":"1997","journal-title":"Gac Med Mex"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4857-7_8"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199911)42:11<2261::AID-ANR1>3.0.CO;2-P"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.10370","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.10370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:40:04Z","timestamp":1696974004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.10370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["10.1002\/art.10370"],"URL":"https:\/\/doi.org\/10.1002\/art.10370","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}