{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:58:06Z","timestamp":1774565886958,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,6,5]],"date-time":"2002-06-05T00:00:00Z","timestamp":1023235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To test in a large open study whether thalidomide is potentially useful in treating ankylosing spondylitis, and to see if thalidomide induces any change in expression of genes in peripheral blood mononuclear cells (PBMC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty male patients with treatment\u2010refractory ankylosing spondylitis were recruited into a 12\u2010month open study using thalidomide at a dosage of 200 mg\/day. Seven indices were measured as primary outcome measures, and 6 other indices as secondary outcome measures. Transcripts in the PBMC of some of these patients were first screened with microarray, and then measured with reverse transcriptase\u2013polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six patients completed the study. Of these, 80% showed a &gt;20% improvement in 4 of 7 primary indices. Sharp declines in several parameters were noticed at 3\u20136 months. Nine patients became pain\u2010free. There was also a statistically significant decrease in tumor necrosis factor \u03b1 transcripts in the PBMC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thalidomide is a reasonably promising drug in treatment\u2010resistant ankylosing spondylitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10396","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:35:39Z","timestamp":1033907739000},"page":"249-254","source":"Crossref","is-referenced-by-count":65,"title":["One\u2010year open\u2010label trial of thalidomide in ankylosing spondylitis"],"prefix":"10.1002","volume":"47","author":[{"given":"Feng","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieruo","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianglin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Tak Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200006)43:6<1346::AID-ANR18>3.0.CO;2-E"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.6.428"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.699"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.2.408"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.6.1675"},{"key":"e_1_2_5_7_2","first-page":"964","article-title":"The effect of thalidomide and 2 analogs on collagen induced arthritis","volume":"25","author":"Oliver SJ","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_5_8_2","first-page":"2344","article-title":"Thalidomide in the treatment of refractory rheumatoid arthritis","volume":"26","author":"Keesal N","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00124743-200002000-00003"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:3<580::AID-ANR27>3.0.CO;2-D"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_5_12_2","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index","volume":"21","author":"Calin A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_5_13_2","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath AS Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00313852"},{"key":"e_1_2_5_15_2","first-page":"966","article-title":"Validity aspects of erythrocyte sedimentation rate and C\u2010reactive protein in ankylosing spondylitis: a literature review","volume":"26","author":"Ruof J","year":"1999","journal-title":"J Rheumatol"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.10396","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.10396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T09:25:57Z","timestamp":1697534757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.10396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,5]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,6,15]]}},"alternative-id":["10.1002\/art.10396"],"URL":"https:\/\/doi.org\/10.1002\/art.10396","archive":["Portico"],"relation":{},"ISSN":["0893-7524","1529-0123"],"issn-type":[{"value":"0893-7524","type":"print"},{"value":"1529-0123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,5]]}}}