{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:36:58Z","timestamp":1782139018945,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,8,9]],"date-time":"2002-08-09T00:00:00Z","timestamp":1028851200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether celecoxib, a selective cyclooxygenase 2 (COX\u20102) inhibitor, cross\u2010reacts in patients with aspirin\u2010exacerbated respiratory disease (AERD) with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty patients with asthma underwent double\u2010blinded, placebo\u2010controlled oral challenges with celecoxib (100 mg, 200 mg, and 2 placebos) over 48 hours in our General Clinical Research Center. The next day, sensitivity to acetylsalicylic acid (ASA) was proven in all patients with the use of single\u2010blinded ASA challenges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the 60 patients experienced any symptoms, changes in nasal examinations, or declines in forced expiratory volume in 1 second during the celecoxib challenges. All 60 patients experienced oculonasal and\/or asthmatic reactions to ASA, with a mean provoking dose of 69 mg. The exact 1\u2010sided confidence interval for the probability of celecoxib inducing cross\u2010reactions in AERD patients was calculated to be between 0% and 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cross\u2010reactivity between ASA and celecoxib does not occur in patients with AERD. These results do not preclude the possibility of other types of immune reactions occurring with celecoxib after prior exposure. Our results add to the growing body of evidence that inhibition of COX\u20101 is a critical initiating event in the precipitation of respiratory reactions in AERD patients following ingestion of nonsteroidal antiinflammatory drugs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10426","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:12:48Z","timestamp":1033906368000},"page":"2201-2206","source":"Crossref","is-referenced-by-count":107,"title":["The safety of celecoxib in patients with aspirin\u2010sensitive asthma"],"prefix":"10.1002","volume":"46","author":[{"given":"Katharine M.","family":"Woessner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald D.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.4.717"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90059-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70123-9"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.11.940"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62221-1"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90106-3"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70106-5"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90174-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80179-4"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03854.x"},{"key":"e_1_2_5_12_2","first-page":"29","article-title":"Tolerability of nimesulide in aspirin\u2010sensitive patients","volume":"72","author":"Andri L","year":"1994","journal-title":"Ann Allergy"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)12154-2"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)91234-X"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110926"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440215"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116290"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01075.x"},{"key":"e_1_2_5_19_2","first-page":"1225","volume-title":"Allergy: principles and practice","author":"Stevenson DD","year":"1998"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62432-5"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-1923-9"},{"key":"e_1_2_5_22_2","first-page":"159","article-title":"Glucocorticosteroids attenuate aspirin\u2010precipitated adverse reactions in aspirin\u2010intolerant patients with asthma","volume":"63","author":"Nizankowska E","year":"1989","journal-title":"Ann Allergy"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.34.5.654"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62575-6"},{"key":"e_1_2_5_25_2","volume-title":"Physicians' Desk Reference","year":"2001"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62327-7"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200112203452518"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.9.3400"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2692"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1871"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.2.9032211"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70106-5"},{"key":"e_1_2_5_33_2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1183\/09031936.93.03050588","article-title":"The cyclooxygenase theory of aspirin\u2010induced asthma","volume":"3","author":"Szczeklik A","year":"1990","journal-title":"Eur Respir J"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90123-6"}],"container-title":["Arthritis &amp; 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