{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:13:12Z","timestamp":1779289992849,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,6,5]],"date-time":"2002-06-05T00:00:00Z","timestamp":1023235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effects of Wegener's granulomatosis (WG) on employment status, work disability, and need for medical care of 60 consecutive WG patients aged \u226440 years at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty WG patients (26 male, 34 female) with a median age of 36 years (range 17\u201348 years) and a median duration of disease of 39 months (range 0\u2013228 months) completed self\u2010administered questionnaires on hospitalization, medical care, and employment status plus the Medical Outcomes Study\u2010Short Form\u201036 (SF\u201036) estimating their health\u2010related quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two of the 60 patients reported full\u2010 or part\u2010time employment more than 3 years after diagnosis. Only 14 of the 51 patients employed at diagnosis (27%) were currently receiving a permanent work disability pension due to WG. Two additional patients had lost work because of WG. Women who were employed at diagnosis had a nearly 3\u2010fold higher risk of losing their jobs compared with men (<jats:italic>P<\/jats:italic> = 0.0006). There were no differences with regard to age at diagnosis, disease duration, disease severity, or education level between employed and unemployed patients. Employed patients had missed a median of 14 workdays (range 0\u201318 days) due to WG within the past 12 months. More than half of all patients (33 of 60) had been hospitalized during the previous 12 months because of WG. Ninety\u2010three percent of all patients had visited their physician once or more per month, more than half of them at least once per week, regardless of employment status, severity of disease, or type of current medication. Unemployed WG patients experienced significant reductions in social and physical function and in their perceived degree of general health as assessed by the SF\u201036.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Twenty\u2010seven percent of WG patients younger than age 40 who were employed at diagnosis received permanent work disability within a disease duration of 39 months. Unemployment is followed by a considerable reduction in disease\u2010related quality of life compared with employed patients, independent of severity and extent of disease. Furthermore, because patients were followed closely by an interdisciplinary team, a high rate of hospitalization and frequent visits to physicians resulted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10458","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:35:39Z","timestamp":1033907739000},"page":"320-325","source":"Crossref","is-referenced-by-count":48,"title":["Effect of Wegener's granulomatosis on work disability, need for medical care, and quality of life in patients younger than 40 years at diagnosis"],"prefix":"10.1002","volume":"47","author":[{"given":"Eva","family":"Reinhold\u2010Keller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Herlyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Wagner\u2010Bastmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Gutfleisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut H.","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner H.","family":"Raspe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang L.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-6-488"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<1021::AID-ANR10>3.0.CO;2-J"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199812)41:12<2257::AID-ART22>3.0.CO;2-K"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330812"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"e_1_2_6_7_2","first-page":"31","article-title":"Development and validation of a disease extent index for ANCA\u2010associated vasculitides","volume":"55","author":"De Groot K","year":"2001","journal-title":"Clin Nephrol"},{"key":"e_1_2_6_8_2","volume-title":"Demographische Standards: Methoden, Verfahren, Entwicklungen","year":"1995"},{"key":"e_1_2_6_9_2","unstructured":"International Standard Classification of OccupationsISCO\u201088.Geneva:International Labor Office;1990."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02959944"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.3.199"},{"key":"e_1_2_6_13_2","first-page":"40","volume-title":"SF36 Fragebogen zum Gesundheitszustand","author":"Bullinger M","year":"1998"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1300\/J013v30n02_07"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2000.140304.x"},{"key":"e_1_2_6_16_2","volume-title":"Population and employment: results from the 1998 microcensus","author":"Federal Statistical Office","year":"1999"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.7.652"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199911)42:11<2495::AID-ANR35>3.0.CO;2-A"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.11.1138"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.6.455"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.11.1130"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001080050745"}],"container-title":["Arthritis Care &amp; 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