{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:51:49Z","timestamp":1791017509608,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T00:00:00Z","timestamp":1034726400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the capacities of the cytokine inhibitors interleukin\u20101 receptor antagonist (IL\u20101Ra; anakinra) and PEGylated soluble tumor necrosis factor receptor I (PEG sTNFRI; pegsunercept) to suppress neovascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A corneal angiogenesis assay was performed by implanting nylon discs impregnated with an angiogenic stimulator (basic fibroblast growth factor or vascular endothelial growth factor) into one cornea of female Sprague\u2010Dawley rats. Animals were treated with IL\u20101Ra or PEG sTNFRI for 7 days, after which new vessels were quantified. In a parallel study, male Lewis rats with mycobacteria\u2010induced adjuvant\u2010induced arthritis were treated with IL\u20101Ra or PEG sTNFRI for 7 days beginning at disease onset, after which scores for inflammation and bone erosion as well as capillary counts were acquired from sections of arthritic hind paws.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with IL\u20101Ra yielded a dose\u2010dependent reduction in growth factor\u2013induced corneal angiogenesis, while PEG sTNFRI did not. IL\u20101Ra, but not PEG sTNFRI, significantly reduced the number of capillaries in arthritic paws, even though both anticytokines reduced inflammation and bone erosion to a similar degree.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data support a major role for IL\u20101, but not TNF\u03b1, in angiogenesis and suggest that an additional antiarthritic mechanism afforded by IL\u20101 inhibitors, but not anti\u2010TNF agents, is the suppression of the angiogenic component of pannus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10546","type":"journal-article","created":{"date-parts":[[2002,10,17]],"date-time":"2002-10-17T19:54:35Z","timestamp":1034884475000},"page":"2604-2612","source":"Crossref","is-referenced-by-count":70,"title":["Inhibition of interleukin\u20101 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant 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