{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:45:47Z","timestamp":1762458347411},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2002,11,8]],"date-time":"2002-11-08T00:00:00Z","timestamp":1036713600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To demonstrate the binding of bovine lipoprotein lipase (LPL) by IgG from sera obtained from patients with systemic lupus erythematosus (SLE) and other rheumatic diseases, and the relationship of anti\u2010LPL to triglyceride levels in SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Binding of LPL by IgG from sera obtained from patients with SLE and other rheumatic diseases was measured by an enzyme\u2010linked immunosorbent assay technique. Lipid profiles for fasting blood samples obtained from SLE patients and control subjects were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sera obtained from 105 patients with SLE were assessed for reactivity with LPL, and 49 (47%) of the results were positive. Sera obtained from patients with rheumatoid arthritis (RA) (n = 80), Sj\u00f6gren's syndrome (n = 30), polymyositis and dermatomyositis (n = 30), and progressive systemic sclerosis (n = 31) were also studied, and 10 (13%), 3 (10%), 12 (40%), and 13 (42%), respectively, were positive for reactivity with LPL. It was determined that all affinity\u2010purified anti\u2013double\u2010stranded DNA (dsDNA) antibodies and 4 of 5 monoclonal anti\u2010dsDNA antibodies bound to LPL. The binding of IgG depleted of anti\u2010dsDNA to LPL indicates a second anti\u2010LPL activity in SLE. Measurements of fasting lipid levels in SLE patients with anti\u2010LPL revealed a strong positive correlation of antibody levels and total serum triglycerides, apolipoprotein B, and apolipoprotein E concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antibodies to LPL occurred in 47% of SLE patients and in a similar percentage of patients with polymyositis or systemic sclerosis. The prevalence of these antibodies was less in patients with RA or Sj\u00f6gren's syndrome. It is hypothesized that the elevated triglyceride levels in SLE patients are in part attributable to anti\u2010LPL, and this lipid abnormality could contribute to the premature atherosclerosis known to be present in patients with SLE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10624","type":"journal-article","created":{"date-parts":[[2002,11,12]],"date-time":"2002-11-12T18:42:32Z","timestamp":1037126552000},"page":"2957-2963","source":"Crossref","is-referenced-by-count":100,"title":["Autoantibodies to lipoprotein lipase and dyslipidemia in systemic lupus erythematosus"],"prefix":"10.1002","volume":"46","author":[{"given":"Morris","family":"Reichlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Fesmire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana I.","family":"Quintero\u2010Del\u2010Rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Wolfson\u2010Reichlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90431-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120300678828226"},{"issue":"9","key":"e_1_2_6_4_2","first-page":"S139","article-title":"Myocardial infarction (MI) and stroke in SLE: markedly increased incidence after controlling for risk factors","volume":"41","author":"Esdaile JM","year":"1998","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310706"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600610"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346979"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80755-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-3-425"},{"issue":"9","key":"e_1_2_6_10_2","first-page":"S79","article-title":"Impaired metabolism of artificial chylomicrons in systemic lupus erythematosus","volume":"41","author":"Borba EF","year":"1998","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2000.4970"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3823907"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/37.5.742"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.1.2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-199604000-00014"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.8.2520"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199609193351203"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.22.2901"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.8.1913"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.14.1629"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.10624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.10624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:35:09Z","timestamp":1697027709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.10624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1002\/art.10624"],"URL":"https:\/\/doi.org\/10.1002\/art.10624","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}