{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:27:29Z","timestamp":1789997249960,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T00:00:00Z","timestamp":1044316800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although recent protocols for standardized knee radiography afford highly reproducible radioanatomic alignment of the joint and measurement of joint space width (JSW) in repeat radiographs acquired on the same day, the sensitivity of these techniques to joint space narrowing (JSN) over time in subjects with knee osteoarthritis (OA) is unknown. The present study was undertaken to compare the metatarsophalangeal (MTP) view and the semiflexed anteroposterior (AP) view with respect to sensitivity to JSN in knee OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 49 subjects with definite knee OA, 2 MTP radiographs and 1 semiflexed AP radiograph were obtained at baseline. Each examination was repeated 14 months later. In MTP views, minimum JSW and the distance between the anterior and posterior margins of the medial tibial plateau (intermargin distance [IMD], an indicator of parallel alignment of the tibial plateau and the x\u2010ray beam) were measured with a pair of calipers and a magnifying lens fitted with a graticule. JSW in semiflexed AP views was measured by digital image analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean of within\u2010knee standard deviations of JSW in the baseline MTP examinations (n = 52 OA knees) was 0.24 mm (coefficient of variation 5.8%). Although IMDs in the 2 baseline MTP views were very highly correlated (+0.88), IMDs in the serial examinations were only moderately correlated (+0.45). Serial MTP views showed a small increase in mean JSW over 14 months that was not significantly greater than zero (mean \u00b1 SD +0.09 \u00b1 0.66 mm; <jats:italic>P<\/jats:italic> not significant). In contrast, concurrent semiflexed AP examinations showed a marginally significant decrease in mean JSW (\u22120.09 \u00b1 0.31 mm; <jats:italic>P<\/jats:italic> = 0.10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results demonstrate that evidence of the short\u2010term reproducibility of a radiographic protocol is an insufficient basis on which to predict the quality of its longitudinal performance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10765","type":"journal-article","created":{"date-parts":[[2003,2,7]],"date-time":"2003-02-07T07:09:02Z","timestamp":1044601742000},"page":"385-390","source":"Crossref","is-referenced-by-count":59,"title":["Detection of radiographic joint space narrowing in subjects with knee osteoarthritis: Longitudinal comparison of the metatarsophalangeal and semiflexed anteroposterior views"],"prefix":"10.1002","volume":"48","author":[{"given":"Steven A.","family":"Mazzuca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Buckwalter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,4]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"65","article-title":"Guidelines for testing slow acting drugs in osteoarthritis","volume":"41","author":"Lequesne M","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_5_3_2","first-page":"799","article-title":"Recommendations for a core set of outcome measures for future phase III clinical trials in knee, hip, and hand osteoarthritis: consensus development at OMERACT III","volume":"24","author":"Bellamy N","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(05)80101-3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.8.761"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1998.0118"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.11.872"},{"key":"e_1_2_5_8_2","first-page":"1359","article-title":"Field test of the reproducibility of automated measurements of medial tibiofemoral joint space width derived from standardized knee radiographs","volume":"26","author":"Mazzuca SA","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_5_9_2","first-page":"2664","article-title":"Substantial superiority of semiflexed (MTP) views in knee osteoarthritis: a comparative radiographic study, without fluoroscopy, of standing extended, semiflexed (MTP), and schuss views","volume":"26","author":"Buckland\u2010Wright JC","year":"1999","journal-title":"J Rheumatol"},{"issue":"9","key":"e_1_2_5_10_2","first-page":"S361","article-title":"Nonfluoroscopic method for flexed radiography of the knee that allows reproducible joint\u2010space width measurement","volume":"41","author":"Peterfy CG","year":"1998","journal-title":"Arthritis Rheum"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200201)46:1<109::AID-ART10040>3.0.CO;2-O"},{"key":"e_1_2_5_12_2","first-page":"1308","article-title":"Which is the best radiographic protocol for a clinical trial of a structure modifying drug in patients with knee osteoarthritis?","volume":"29","author":"Brandt KD","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_5_14_2","first-page":"427","volume-title":"Osteoarthritic disorders","author":"Lequesne M","year":"1995"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(05)80327-9"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7059.744"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1302\/0301-620X.72B4.2380220","article-title":"Anteroposterior radiographs of the osteoarthritic knee","volume":"72","author":"Messieh SS","year":"1990","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10256"}],"container-title":["Arthritis &amp; 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