{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:50:56Z","timestamp":1775915456734,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,4,4]],"date-time":"2003-04-04T00:00:00Z","timestamp":1049414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2003,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine variables associated with bone mineral density (BMD) and vertebral deformities in women with rheumatoid arthritis (RA) from 3 northwest European countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female patients were recruited from rheumatology clinics in Oslo, Norway; Truro, UK; and Amsterdam, The Netherlands (150 total, 50 per center, age 50\u201370 years, disease duration \u22655 years). Demographic and clinical data were collected and BMD was measured by means of dual energy x\u2010ray absorptiometry. Associations between demographic and clinical measures on the one hand and BMD and vertebral deformities on the other were investigated by single and multiple regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body mass index (BMI), medication use, RA damage measures, and BMD differed significantly between the 3 centers. Overall, Norwegian patients had the lowest BMI, used more corticosteroids and antiosteoporotic drugs, had lower joint damage measured by Larsen score, and lower BMD at both spine and hip. High age, low BMI, and high cumulative dose of corticosteroids (last 2 years) are related to low BMD. A high Larsen score was associated with low BMD at the hip. Larsen score was the independent determinant of vertebral deformities after correction for center, age, BMI, and BMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data from 3 countries on BMD and vertebral deformities in female patients aged 50\u201370 years with longstanding RA are presented, demonstrating an association between radiographic RA damage and low BMD and between radiographic RA damage and vertebral deformities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10996","type":"journal-article","created":{"date-parts":[[2003,4,7]],"date-time":"2003-04-07T15:02:28Z","timestamp":1049727748000},"page":"209-215","source":"Crossref","is-referenced-by-count":72,"title":["Radiographic damage associated with low bone mineral density and vertebral deformities in rheumatoid arthritis: The Oslo\u2010Truro\u2010Amsterdam (OSTRA) collaborative study"],"prefix":"10.1002","volume":"49","author":[{"given":"Mariette C.","family":"Lodder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Haugeberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem F.","family":"Lems","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Uhlig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragnhild E.","family":"Orstavik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet J.","family":"Kostense","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben A. C.","family":"Dijkmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore K.","family":"Kvien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Woolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.4.309"},{"key":"e_1_2_6_3_2","first-page":"2541","article-title":"The skeleton in rheumatoid arthritis: common mechanisms for bone erosion and osteoporosis?","volume":"27","author":"Sambrook PN","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)43:2<250::AID-ANR3>3.0.CO;2-P"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<522::AID-ANR7>3.0.CO;2-Y"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200012)43:12<2776::AID-ANR18>3.0.CO;2-N"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.6.325"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361105"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.1.43"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.10.805"},{"key":"e_1_2_6_12_2","first-page":"381","article-title":"Bone mineral density in ambulant, non\u2010steroid treated female patients with rheumatoid arthritis","volume":"11","author":"Eggelmeijer F","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91049-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.1.21"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.1.18"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.2.91"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6877.558"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.5.521"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.1.49"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_23_2","first-page":"1974","article-title":"How to apply Larsen score in evaluating radiographs of rheumatoid arthritis in long\u2010term studies","volume":"22","author":"Larsen A","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080915"},{"key":"e_1_2_6_26_2","first-page":"2299","article-title":"Bone mineral density measured by dual X\u2010ray absorptiometry: a reference material from Oslo","volume":"116","author":"Falch JA","year":"1996","journal-title":"Tidsskr Nor Laegeforen"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.70.840.9505843"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-6009(08)80203-6"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090802"},{"key":"e_1_2_6_30_2","first-page":"2582","article-title":"A multicenter cross sectional study on bone mineral density in rheumatoid arthritis. Italian Study Group on Bone Mass in Rheumatoid Arthritis","volume":"27","author":"Sinigaglia L","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_31_2","first-page":"1063","article-title":"Osteoporosis with low dose corticosteroids: contribution of underlying disease effects and discriminatory ability of ultrasound versus bone densitometry","volume":"28","author":"Sambrook P","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050224"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280402"},{"key":"e_1_2_6_34_2","first-page":"293","article-title":"Vertebral fractures in patients with rheumatoid arthritis treated with corticosteroids","volume":"13","author":"Lems WF","year":"1995","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.19.2917"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.12.1383"},{"key":"e_1_2_6_37_2","first-page":"1495","article-title":"Limited bone loss due to corticosteroids; a systematic review of prospective studies in rheumatoid arthritis and other diseases","volume":"24","author":"Verhoeven AC","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330302"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271205"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.10996","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.10996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:44:58Z","timestamp":1697039098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.10996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,4,15]]}},"alternative-id":["10.1002\/art.10996"],"URL":"https:\/\/doi.org\/10.1002\/art.10996","archive":["Portico"],"relation":{},"ISSN":["0893-7524","1529-0123"],"issn-type":[{"value":"0893-7524","type":"print"},{"value":"1529-0123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,4]]}}}