{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:53:44Z","timestamp":1790855624017,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if geoclimatic factors may influence the nature and frequency of dermatomyositis (DM), polymyositis, and associated autoantibodies around the world.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed, in the first global evaluation of these conditions, the relationship between 13 geoclimatic variables that may modulate disease and the relative proportion of DM and its associated autoantibody anti\u2013Mi\u20102, directed against an SNF2\u2010superfamily helicase associated with the nucleosome remodeling and histone acetylation and deacetylation complex, in a global myositis population. Altogether, 919 consecutive patients from populations at 15 locations were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate and multivariate analyses demonstrated that of the variables evaluated, surface ultraviolet (UV) radiation intensity (irradiance) most strongly contributed to the relative proportion of DM and was strongly related to the proportion of anti\u2013Mi\u20102 autoantibodies (weighted r = 0.939, <jats:italic>P<\/jats:italic> &lt; 4 \u00d7 10<jats:sup>\u20107<\/jats:sup> and weighted r = 0.69, <jats:italic>P<\/jats:italic> = 0.02, respectively). Published ethnogeographic immunogenetic allele frequencies imply that the striking differences in the proportion of DM\u2010 and DM\u2010specific autoantibodies observed around the world are not the result of inherent global variations in known genetic risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that UV radiation exposure may modulate the clinical and immunologic expression of an autoimmune disease in different populations around the world.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.11090","type":"journal-article","created":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T17:38:48Z","timestamp":1060018728000},"page":"2285-2293","source":"Crossref","is-referenced-by-count":157,"title":["Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease"],"prefix":"10.1002","volume":"48","author":[{"given":"Satoshi","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Weatherhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira N.","family":"Targoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wesley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0901-759"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107s5667"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00220-9"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v21.i4.40"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1996.tb03054.x"},{"issue":"1","key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/jid.1995.14","article-title":"Involvement of cytokines, DNA damage, and reactive oxygen intermediates in ultraviolet radiation\u2010induced modulation of intercellular adhesion molecule\u20101 expression","volume":"105","author":"Krutmann J","year":"1995","journal-title":"J Invest Dermatol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00378.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2001.01047.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02898.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(00)00087-7"},{"key":"e_1_2_6_12_2","first-page":"1562","volume-title":"Arthritis and allied conditions, a textbook of rheumatology","author":"Miller FW","year":"2000"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1996.tb05660.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199111000-00002"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390910"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80180-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199711000-00007"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.270.15.1846"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.12.2517"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116493"},{"key":"e_1_2_6_22_2","volume-title":"Climatological normals for the period 1961\u20131990","year":"1996"},{"key":"e_1_2_6_23_2","volume-title":"World Weather Records 1971\u201380","year":"1989"},{"key":"e_1_2_6_24_2","volume-title":"World Weather Records 1981\u20131990","year":"1995"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/berh.1999.0076"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.2.141"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1029\/95GL00111"},{"key":"e_1_2_6_28_2","first-page":"17","article-title":"A reference action spectrum for ultraviolet induced erythema in human skin","volume":"6","author":"McKinlay AF","year":"1987","journal-title":"CIE J"},{"key":"e_1_2_6_29_2","unstructured":"Erythema Reference Action Spectrum and Standard Erythema Dose Joint ISO\/CIE Standard.Commission Internationale de l'Eclairage (CIE). 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