{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:14:15Z","timestamp":1793394855990,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,7,2]],"date-time":"2003-07-02T00:00:00Z","timestamp":1057104000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Because anti\u2013tumor necrosis factor \u03b1 (anti\u2010TNF) has emerged as a highly effective treatment for numerous inflammatory arthritides, which are a common cause of AA amyloidosis, we retrospectively evaluated the safety and efficacy of anti\u2010TNF in a nationwide study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The rheumatology departments of all French teaching hospitals were contacted by mail to obtain the files of patients with histologically proven secondary AA amyloidosis and renal involvement who were treated with anti\u2010TNF. Efficacy was assessed as a sustained decrease in 24\u2010hour proteinuria and a stable\/improved glomerular filtration rate (GFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 15 patients studied, the 24\u2010hour proteinuria was 4.5 \u00b1 3.6 gm (mean \u00b1 SD), creatininemia was 178.4 \u00b1 74.9 \u03bcmoles\/liter, and GFR was 46 \u00b1 23 ml\/minute before starting anti\u2010TNF. Ten patients received infliximab, 4 received etanercept, and 1 received both types of treatment. The mean followup was 10.4 months. No severe adverse events were recorded; one episode of herpes zoster in the first branch of the trigeminal nerve occurred after one infusion of infliximab. Amyloidosis progressed in 7 patients and was stabilized in 5 patients. Three patients (receiving infliximab alone, infliximab plus methotrexate [MTX], or etanercept plus MTX) experienced rapid, dramatic, and sustained decreases in proteinuria (\u226580%), with the GFR increasing 15\u201378%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010TNF was well\u2010tolerated and safe in the 15 patients with AA amyloidosis and renal involvement. The pathogenic role of TNF in AA amyloidosis, the sustained proteinuria decrease in 3 patients, and the stabilization of renal parameters in 5 other patients make anti\u2010TNF a promising candidate to treat AA amyloidosis secondary to inflammatory arthritides.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.11163","type":"journal-article","created":{"date-parts":[[2003,7,3]],"date-time":"2003-07-03T10:03:27Z","timestamp":1057226607000},"page":"2019-2024","source":"Crossref","is-referenced-by-count":187,"title":["Anti\u2013tumor necrosis factor \u03b1 therapy in fifteen patients with AA amyloidosis secondary to inflammatory arthritides: A followup report of tolerability and efficacy"],"prefix":"10.1002","volume":"48","author":[{"given":"Jacques\u2010Eric","family":"Gottenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Merle\u2010Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Bentaberry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Allanore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Berenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Fautrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Combe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Durbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Sibilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780381220"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(98)70154-4"},{"key":"e_1_2_5_4_2","first-page":"898","article-title":"Chlorambucil in severe juvenile chronic arthritis: longterm follow\u2010up with special reference to amyloidosis","volume":"26","author":"Savolainen HA","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_5_5_2","first-page":"85","article-title":"Amyloidosis in juvenile chronic arthritis: a morbidity and mortality study","volume":"11","author":"David J","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_5_7_2","first-page":"376","article-title":"Systemic amyloidosis: a clinical survey of 144 cases","volume":"29","author":"Janssen S","year":"1986","journal-title":"Neth J Med"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010053431412"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10581"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200001000-00012"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1993.tb01660.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001235200"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/76216"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.11163","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.11163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:44:37Z","timestamp":1698713077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.11163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1002\/art.11163"],"URL":"https:\/\/doi.org\/10.1002\/art.11163","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}