{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:54:23Z","timestamp":1791258863256,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,9,11]],"date-time":"2003-09-11T00:00:00Z","timestamp":1063238400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sonderforschungsbereich","award":["SFB293"],"award-info":[{"award-number":["SFB293"]}]},{"name":"IZKF M\u00fcnster","award":["C16"],"award-info":[{"award-number":["C16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze which cellular compartments are involved in the initial phase of systemic\u2010onset juvenile rheumatoid arthritis (JRA), and to investigate the role that myeloid\u2010related protein 8 (MRP\u20108) and MRP\u201014, two S\u2010100 proteins that are primarily expressed in phagocytes, play in the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin biopsy samples obtained during patients' acute episodes of systemic\u2010onset JRA were analyzed by immunohistochemistry and in situ hybridization. Concentrations of MRP\u20108\/MRP\u201014 in serum were determined by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By analyzing biopsy samples from cutaneous rashes during the initial phase of systemic\u2010onset JRA, we discovered infiltration of leukocytes expressing MRP\u20108 and MRP\u201014. Surprisingly, keratinocytes also showed de novo synthesis of these proinflammatory proteins, indicating activation of epithelial cells during systemic\u2010onset JRA. Serum concentrations of MRP\u20108\/MRP\u201014 were 120\u2010fold higher compared with healthy controls and \u223c12\u2010fold higher compared with patients with other inflammatory diseases. Concentrations of MRP\u20108\/MRP\u201014 in patients with systemic\u2010onset JRA fell dramatically after remission was induced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The exceptionally high serum levels of MRP\u20108 and MRP\u201014 in active systemic\u2010onset JRA make them prime candidates as markers for monitoring disease activity and response to treatment. Since MRP\u20108\/MRP\u201014 exhibit direct effects on leukocyte adhesion to the vascular endothelium, their extensive expression in the epidermis indicates an active role for these S\u2010100 proteins in the initial phase of this systemic autoimmune disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.11177","type":"journal-article","created":{"date-parts":[[2003,9,16]],"date-time":"2003-09-16T14:43:17Z","timestamp":1063723397000},"page":"2622-2626","source":"Crossref","is-referenced-by-count":113,"title":["Expression of myeloid\u2010related proteins 8 and 14 in systemic\u2010onset juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"48","author":[{"given":"Michael","family":"Frosch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vogl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Seeliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Wulffraat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wietse","family":"Kuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Viemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Foell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Sorg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cord","family":"Sunderk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60640-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)44:10<2224::AID-ART384>3.0.CO;2-H"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<628::AID-ANR20>3.0.CO;2-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.3.1034-1043.2003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00062-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241012"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.6.1875.1875"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63986-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80259-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1681\/ASN.V1291947","article-title":"An increase in myeloid\u2010related protein serum levels precedes acute renal allograft rejection","volume":"12","author":"Burkhardt K","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.3.367"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104871200"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11683-7"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00372067"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100670170100"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01451062"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.11177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.11177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T19:55:07Z","timestamp":1698782107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.11177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1002\/art.11177"],"URL":"https:\/\/doi.org\/10.1002\/art.11177","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}