{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:59:09Z","timestamp":1791248349128,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2003,10,7]],"date-time":"2003-10-07T00:00:00Z","timestamp":1065484800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fund for Scientific Research Flanders, the regional government of Flanders"},{"name":"Belgian federal government (Interuniversity Network for Fundamental Research)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Male DBA\/1 mice are known to spontaneously develop arthritis in the hind legs. The present study was undertaken to investigate the role of endogenous interferon\u2010\u03b3 (IFN\u03b3) in the pathogenesis of this ankylosing enthesopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The role of IFN\u03b3 was studied by examining the development of arthritis in IFN\u03b3 receptor\u2013knockout (IFN\u03b3R\u2010KO) DBA\/1 mice as compared with wild\u2010type mice, and by treatment of wild\u2010type mice with monoclonal anti\u2010IFN\u03b3 antibody. IFN\u03b3\u2010disrupted and wild\u2010type mice were mixed and housed in the same cage, and clinical symptoms of arthritis were assessed weekly for at least 9 weeks. Histologic examination was performed at the end of the experiment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In DBA\/1 wild\u2010type mice, 70% of the animals developed clinical symptoms of spontaneous arthritis, such as redness and swelling of the proximal interphalangeal joints, toe stiffness, and ankylosis. As evident from microscopic evaluation, the arthritis was mainly characterized by formation of new cartilage and bone, originating at the entheses and leading to ankylosis. The incidence and severity of arthritis, both clinically and histologically, were significantly reduced in IFN\u03b3R\u2010KO mice. In wild\u2010type mice, neutralizing anti\u2010IFN\u03b3 antibody inhibited the occurrence of the disease for the duration of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that endogenous IFN\u03b3 plays an important role in the initial stages of spontaneous arthritis, and that the inflammatory components in its pathogenesis are more prominent than has been believed. In view of the similarity between this disease and spondylarthropathies in humans, the data suggest that endogenous IFN\u03b3 may also play a disease\u2010promoting role in the human condition and thus may serve as a target for therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.11273","type":"journal-article","created":{"date-parts":[[2004,6,2]],"date-time":"2004-06-02T14:21:02Z","timestamp":1086186062000},"page":"2983-2988","source":"Crossref","is-referenced-by-count":23,"title":["Dependence on interferon\u2010\u03b3 for the spontaneous occurrence of arthritis in DBA\/1 mice"],"prefix":"10.1002","volume":"48","author":[{"given":"Patrick","family":"Matthys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik J.","family":"Lories","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Bert De Klerck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertine","family":"Heremans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank P.","family":"Luyten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons","family":"Billiau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)01937-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.4049\/jimmunol.163.6.3503","article-title":"Enhanced autoimmune arthritis in IFN\u2010\u03b3 receptor\u2010deficient mice is conditioned by mycobacteria in Freund's adjuvant and by increased expansion of Mac\u20101+ myeloid cells","volume":"163","author":"Matthys P","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.4049\/jimmunol.158.11.5507","article-title":"Accelerated collagen\u2010induced arthritis in interferon\u2010\u03b3 receptor\u2010deficient mice","volume":"158","author":"Vermeire K","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.4049\/jimmunol.158.11.5501","article-title":"High susceptibility to collagen\u2010induced arthritis in mice lacking IFN\u2010\u03b3 receptors","volume":"158","author":"Manoury\u2010Schwartz B","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830261020"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250508"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb03399.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.4.447"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200004)43:4<844::AID-ANR15>3.0.CO;2-B"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350619"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06473.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.3.213"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2001.19950503.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.4.263"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456301"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-996-0014-6"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4450"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.1.78"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.11273","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.11273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:30:16Z","timestamp":1697027416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.11273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1002\/art.11273"],"URL":"https:\/\/doi.org\/10.1002\/art.11273","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}