{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:48:27Z","timestamp":1792759707348,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2003,12,8]],"date-time":"2003-12-08T00:00:00Z","timestamp":1070841600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the mortality of giant cell arteritis (GCA) with large\u2010artery complication compared with that of GCA without large\u2010artery complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An inception cohort of 168 residents of Olmsted County, Minnesota, in whom GCA was diagnosed between January 1, 1950, and December 31, 1999, was followed up. Mortality in patients with incident large\u2010artery complication (aortic aneurysm, aortic dissection, and large\u2010artery stenosis) was determined and compared with that in patients in whom large\u2010artery complication did not develop.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference in survival was observed between the total group of patients with any type of large\u2010artery complication and patients without large\u2010artery complication or the general population. However, mortality was markedly increased in the 9 patients in whom thoracic aortic dissection developed (median survival 1.1 years [interquartile range 0.2\u20137.8 years]) compared with that in all other patients with GCA (<jats:italic>P<\/jats:italic>&lt; 0.001). No difference in survival was observed between the group of patients with either aortic aneurysm and\/or dissection (thoracic and\/or abdominal aorta) and the group with GCA without large\u2010artery complication. Survival of patients with GCA and large\u2010artery stenosis was not different from that of patients with GCA without large\u2010artery complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thoracic aortic dissection in GCA is associated with markedly increased mortality. Overall, mortality in the whole group of patients with GCA with large\u2010artery complication was similar to that in patients with GCA without large\u2010artery complication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.11480","type":"journal-article","created":{"date-parts":[[2003,12,9]],"date-time":"2003-12-09T09:00:36Z","timestamp":1070960436000},"page":"3532-3537","source":"Crossref","is-referenced-by-count":172,"title":["Mortality of large\u2010artery complication (aortic aneurysm, aortic dissection, and\/or large\u2010artery stenosis) in patients with giant cell arteritis: A population\u2010based study over 50 years"],"prefix":"10.1002","volume":"48","author":[{"given":"Dirk M.","family":"Nuenninghoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene G.","family":"Hunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa J. H.","family":"Christianson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"McClelland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Matteson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300308"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310607"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370705"},{"key":"e_1_2_5_5_2","first-page":"1739","article-title":"The incidence of polymyalgia rheumatica and temporal arteritis in the county of Aust Agder, south Norway: a prospective study 1987\u201094","volume":"24","author":"Gran JT","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_5_6_2","first-page":"2624","article-title":"Temporal arteritis in Vest Agder County in southern Norway: incidence and clinical findings","volume":"27","author":"Haugeberg G","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_5_7_2","first-page":"345","article-title":"A case of temporal arteritis (CPC)","volume":"42","author":"Sproul E","year":"1942","journal-title":"N Y State J Med"},{"key":"e_1_2_5_8_2","first-page":"63","article-title":"Diffuse granulomatous aortitis with giant cells associated with partial rupture and dissection of the aorta","volume":"49","author":"McMillan G","year":"1950","journal-title":"Arch Pathol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700620318"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.19.2.206"},{"key":"e_1_2_5_11_2","first-page":"1","article-title":"Polymyalgia arteritica","volume":"533","author":"Hamrin B","year":"1972","journal-title":"Acta Med Scand"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.0954-6820.1972.tb15615.x","article-title":"Morphological changes in the large arteries in polymyalgia arteritica","volume":"533","author":"Oestberg G","year":"1972","journal-title":"Acta Med Scand"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00424-6"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-7-199504010-00004"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371020"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)86182-6"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-6-806"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199902)42:2<311::AID-ANR14>3.0.CO;2-F"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.3.352"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1986.tb02778.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-3-199508010-00006"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)89458-2"},{"key":"e_1_2_5_23_2","first-page":"2171","article-title":"Giant cell arteritis in Lugo, Spain, is associated with low longterm mortality","volume":"24","author":"Gonzalez\u2010Gay MA","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_5_24_2","first-page":"737","article-title":"Increased mortality due to cardiovascular disease in patients with giant cell arteritis in northern Sweden","volume":"29","author":"Uddhammar A","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6698.549"},{"key":"e_1_2_5_26_2","first-page":"1283","article-title":"Analysis of steroid related complications and mortality in temporal arteritis: a 15\u2010year survey of 43 patients","volume":"21","author":"Nesher G","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_5_27_2","first-page":"1103","article-title":"Thoracic aortic aneurysms: a population\u2010based study","volume":"92","author":"Bickerstaff LK","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113902"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.3.266"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330810"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11353"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1991.tb00418.x"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6260.269"}],"container-title":["Arthritis &amp; 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