{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:35Z","timestamp":1791300515226,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,1,9]],"date-time":"2004-01-09T00:00:00Z","timestamp":1073606400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the long\u2010term outcome and associated clinical, serologic, and pathologic features in a cohort of patients with connective tissue disease (CTD) and the anti\u2013signal recognition particle (anti\u2010SRP) autoantibody.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sera and clinical data were collected prospectively from consecutive adult patients with polymyositis (PM; n = 134), dermatomyositis (n = 129), or other CTDs (predominantly systemic sclerosis [SSc; n = 790]). Patients were first evaluated during 1973\u20132001.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen patients with the anti\u2010SRP autoantibody were identified, 16 (84%) of whom had pure PM and 3 (2 with SSc and 1 with antisynthetase syndrome) had yet to develop features of myositis after a mean followup of 4.5 years (range 2.5\u20136 years). More SRP\u2010positive PM patients had severe proximal muscle weakness (50%) and muscle atrophy (67%) at initial presentation compared with antisynthetase\u2010positive PM controls. Cardiac involvement occurred in only 2 of 16 SRP\u2010positive PM patients (13%), and interstitial lung disease was noted in 3 of 13 SRP\u2010positive PM patients (23%) and in the 3 SRP\u2010positive nonmyositis patients. There was a relative lack of inflammation in muscle biopsy specimens from the SRP\u2010positive PM cohort. Other autoantibodies in the SRP\u2010positive patients included Ro\/SSA (4 patients), Th\/To (1 patient), and anti\u2013PL\u201012 (1 patient). Survival in the SRP\u2010positive PM patients was comparable with that seen in the cohort of SRP\u2010negative PM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The anti\u2010SRP autoantibody is not specific for PM. Severe muscle weakness and atrophy were prominent features in PM patients with anti\u2010SRP. Cardiac involvement was less common and survival was better in patients with anti\u2010SRP than has previously been reported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.11484","type":"journal-article","created":{"date-parts":[[2004,1,13]],"date-time":"2004-01-13T07:02:17Z","timestamp":1073977337000},"page":"209-215","source":"Crossref","is-referenced-by-count":245,"title":["Anti\u2013signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy"],"prefix":"10.1002","volume":"50","author":[{"given":"Amy H.","family":"Kao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lacomis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreen","family":"Fertig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester V.","family":"Oddis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.270.15.1846"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330908"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199111000-00002"},{"key":"e_1_2_6_5_2","first-page":"B6.1\/1","volume-title":"Manual of biologic markers of disease","author":"Plotz P","year":"1994"},{"issue":"9","key":"e_1_2_6_6_2","first-page":"S611","article-title":"Clinical features of Japanese patients with anti\u2010SRP autoantibodies: the immunogenetic backgrounds","volume":"46","author":"Hirakata M","year":"2002","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.2.116"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9507"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.4049\/jimmunol.138.10.3219","article-title":"Characterization of human autoantibodies that selectively precipitate the 7SL RNA component of the signal recognition particle","volume":"138","author":"Okada N","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261107"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350114"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.5.1281"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390424"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10760"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199905000-00001"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.4.420"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.11484","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.11484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T20:28:37Z","timestamp":1698697717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.11484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/art.11484"],"URL":"https:\/\/doi.org\/10.1002\/art.11484","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}