{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:47:04Z","timestamp":1777542424286,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":17401,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1958,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An extensive study of the relationship of peptic ulcer to adrenal steroid therapy has led to the conclusion that certain corticosteroids are responsible for gastric ulceration, probably as a result of direct effects on the mucosa.<\/jats:p><jats:p>Peptic ulcer was observed radiographically in 31 per cent of patients with rheumatoid arthritis receiving adrenal steroids but in only 9 per cent of patients not treated and 5 per cent of nonrheumatoid controls. Hydrochloric acid and pepsin secretion were not influenced significantly by the administration of corticosteroids.<\/jats:p><jats:p>Un extense studio del relation inter ulcere peptic e therapia adreno\u2010steroide ha resultate in le conclusion que certe corticosteroides es responsabile pro ulceration gastric, probabilemente in consequentia de effectos directe super le mucosa.<\/jats:p><jats:p>Ulcere peptic esseva observate radio\u2010graphicamente in 31 pro cento de patientes con arthritis rheumatoide qui recipeva steroides adrenal sed solmente in 9 pro cento de tal patientes qui non recipeva steroides adrenal e in 5 pro cento de non\u2010rheumatoide subjectos de controlo. Le secretion de acido hydrochloric e de pepsina non esseva influentiate a grados significative per le administration de corticosteroides.<\/jats:p>","DOI":"10.1002\/art.1780010205","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:52:55Z","timestamp":1171457575000},"page":"122-141","source":"Crossref","is-referenced-by-count":51,"title":["Peptic ulcer in rheumatoid patients on corticosteroid therapy. A clinical, experimental and radiologic study"],"prefix":"10.1002","volume":"1","author":[{"given":"William H.","family":"Kammerer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Freiberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham L.","family":"Rivelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"41","article-title":"Peptic ulcer: Review of recent literature pertaining to etiology, pathogenesis and certain clinical aspects","volume":"8","author":"Kirsner J. B.","journal-title":"Advances Int. Med."},{"key":"e_1_2_1_3_2","first-page":"3","article-title":"Is there a relationship between peptic ulcer and the adrenal glands?","volume":"2","author":"Gastroenterology Research Group","year":"1957","journal-title":"Am. J. Dig. Dis."},{"key":"e_1_2_1_4_2","first-page":"899","article-title":"The effect of adrenocorticotrophic hormone upon uropepsin excretion","volume":"35","author":"Spiro H. M.","year":"1950","journal-title":"J. Lab. & Clin. Med."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1951.03670330021007"},{"key":"e_1_2_1_6_2","first-page":"244","article-title":"Hormonal influences upon the stomach","volume":"24","author":"Gray S. J.","year":"1955","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1955.02960010029007"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)36103-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(52)91358-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1956.02960430003002"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1956.02960480068019"},{"key":"e_1_2_1_12_2","unstructured":"Meltzer L. E. Bockman A. D. Dunsmore A.andCohen A.:The incidence of peptic ulcer formation among patients on long\u2010term prednisone therapy. Read at Ninth International Congress on Rheumatic Diseases June23\u201328.1957 Toronto Canada."},{"key":"e_1_2_1_13_2","first-page":"609","article-title":"New developments in steroid therapy of rheumatic diseases","volume":"52","author":"Henderson E.","year":"1955","journal-title":"J. Med. Soc. New Jersey."},{"key":"e_1_2_1_14_2","first-page":"4","volume":"14","author":"Experience with Cortisone in the management of rheumatoid arthritis. Report of a cooperative study conducted by a committee of the American Rheumatism Association.","year":"1955","journal-title":"Ann. Rheomat. Dis."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-195605000-00001"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0016-5085(19)35785-3","article-title":"Peptic ulceration occurring during therapy for rheumaotid arthritis","volume":"33","author":"Kern F.","year":"1957","journal-title":"Gastroenterology"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(57)90082-6"},{"key":"e_1_2_1_18_2","first-page":"159","article-title":"A simplified method for determining he excretion rate of uropepsin","volume":"39","author":"West P. M.","year":"1952","journal-title":"J. Lab. Clin. 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Council Special Report Series No. 276 1951."}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780010205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780010205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:51:18Z","timestamp":1700761878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780010205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1958,4]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1958,4]]}},"alternative-id":["10.1002\/art.1780010205"],"URL":"https:\/\/doi.org\/10.1002\/art.1780010205","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1958,4]]}}}