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These patients almost always had subcutaneous nodules, which were not always associated with a high latex titer for rheumatoid factor. Necrotizing vasculitis occurred in both antinuclear factor positive and negative patients. Our data do not support the notion that a positive antinuclear factor test or a positive L.E. cell test should be used to exclude the diagnosis of rheumatoid arthritis.<\/jats:p>","DOI":"10.1002\/art.1780080607","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T15:22:03Z","timestamp":1171466523000},"page":"1080-1093","source":"Crossref","is-referenced-by-count":39,"title":["The significance of antinuclear factors in rheumatoid arthritis"],"prefix":"10.1002","volume":"8","author":[{"given":"John J.","family":"Condemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene V.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward C.","family":"Atwater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph F.","family":"Jacox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward S.","family":"Mongan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recipientjohn H.","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","article-title":"Localization of antigen in tissue cells. 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