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The tissues were examined with three test systems: 1) Sheep erythrocytes sensitized by rabbit antiserum, 2) human O Rh\u2010positive (CD) erythrocytes sensitized by anti\u2010Rh serum \u201cRipley,\u201d and 3) rabbit erythrocytes sensitized with mercaptoethanol\u2010treated pooled human serum. Adsorption of the sensitized cells to the tissue sections was obtained in most of the cases. This mixed agglutination was inhibited by denatured \u0393\u2010globulin and by antibodies to \u03b3M, indicating that the reaction depended on RF bound in the synovial tissue. Of 31 patients with rheumatoid arthritis, tissue from 30 gave positive reactions. Tissue from many patients also gave a positive reaction with RF applied to the tissue, indicating that the reactant for RF is bound in the tissue.<\/jats:p>","DOI":"10.1002\/art.1780110403","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T15:33:19Z","timestamp":1171467199000},"page":"537-545","source":"Crossref","is-referenced-by-count":21,"title":["Demonstration of rheumatoid factor in tissue by mixed agglutination with tissue sections"],"prefix":"10.1002","volume":"11","author":[{"given":"E. 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W.","year":"1958","journal-title":"Bull. Rheum. Dis."},{"key":"e_1_2_1_16_2","unstructured":"Larsen B. andT\u00f6nder O.:Production of specific antisera to m\u0308G and m\u0308M globulins. In preparation."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1966.tb04244.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780080204"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.65.3.467"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780090507"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.106.5.689"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1958.tb04899.x"},{"key":"e_1_2_1_23_2","first-page":"356","article-title":"Reaction of rheumatoid sera with synovial tissue as revealed by fluorescent antibody studies","volume":"2","author":"Kaplan M. 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