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The cells were stained by the direct fluorescent antibody technique for IgG, IgM and the \u03b2<jats:sub>1c<\/jats:sub> (C3) component of complement, using fluorescein and rhodamine isothiocyanate\u2010labeled antisera. A characteristic diffuse staining pattern for IgG and \u03b2<jats:sub>1c<\/jats:sub> was observed in the cytoplasm of the phagocytic lining cells of rheumatoid synovium. In seropositive patients, inclusions containing IgG, IgM, and \u03b2<jats:sub>1c<\/jats:sub> were also stained in these cells. The role of these immunoglobulins, localized in the lining cells, is discussed in relation to rheumatoid inflammation.<\/jats:p>","DOI":"10.1002\/art.1780130603","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:15:48Z","timestamp":1171469748000},"page":"734-753","source":"Crossref","is-referenced-by-count":63,"title":["Studies of isolated synovial lining cells of rheumatoid and nonrheumatoid synovial membranes"],"prefix":"10.1002","volume":"13","author":[{"given":"T.","family":"Douglas Kinsella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Baum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Ziff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"853","article-title":"Fine structure and cytochemistry of the rheumatoid synovial membrane, with special reference to lysosomes","volume":"44","author":"Barland P","year":"1964","journal-title":"Amer J Path"},{"key":"e_1_2_1_3_2","first-page":"519","article-title":"The fine structure of synovial lining cells in rheumatoid arthritis","volume":"15","author":"Wyllie JC","year":"1966","journal-title":"Lab Invest"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780090405"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.26.5.426"},{"key":"e_1_2_1_6_2","first-page":"195","article-title":"Fine structures of the synovial tissues in rheumatoid arthritis","volume":"10","author":"Hirohata K","year":"1964","journal-title":"Kobe J Med Sci"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.4049\/jimmunol.88.4.519","article-title":"Phagocytosis of particulate complexes of \u03b3\u2010globulin and rheumatoid factor","volume":"88","author":"Parker RL","year":"1962","journal-title":"J Immunol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-62-2-271"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-62-2-281"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-62-2-285"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110202"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110203"},{"key":"e_1_2_1_13_2","unstructured":"KaplanMH VaughanJ: Conference on host response mechanisms in rheumatoid arthritis Arthritis and Rheumatism Foundation Conference Series. 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