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Certain extra\u2010articular manifestations of rheumatoid arthritis were found in higher incidence in the group of patients with eosinophilia. The most notable of these were vasculitis, pleuropericarditis, pulmonary fibrosis and subcutaneous nodules. The eosinophilia was present for variable periods of time, sometimes persisting at elevated levels for several years or alternatively appearing in brief episodes. In a number of patients, the appearance in time of some extra\u2010articular manifestations was coincident with eosinophilia. Two patients had extreme elevations in the number of eosinophiles. The eosinophiles of one patient, studied in detail, showed inclusions, which by immunofluorescent microscopy, contained \u03b3G\u2010globulin, \u03b3M\u2010globulin and rheumatoid factor. The serum of this patient when incubated with another eosinophile preparation induced the formation of inclusions. Various mechanisms were discussed in which the eosinophilia is related to possible immune events occurring in the course of rheumatoid arthritis.<\/jats:p>","DOI":"10.1002\/art.1780140513","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:02:18Z","timestamp":1171468938000},"page":"650-665","source":"Crossref","is-referenced-by-count":68,"title":["Observations on the eosinophilia of certain patients with rheumatoid arthritis"],"prefix":"10.1002","volume":"14","author":[{"given":"R. J.","family":"Winchester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Litwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Koffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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