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In patients receiving cyclophosphamide, all three types of immunoglobulin\u2010staining varieties of circulating B lymphocytes were significantly decreased. At the same time the circulating T lymphocytes were also significantly reduced. In patients with scleroderma trcated with therapeutic doses of cyclophosphamide and studied sequentially, the reduction in B lymphocytes oc\u2010curred first, with eventual depletion of both cell types. In 2 patients, an early rebound increase in T cells occurred followed by a marked reduction. These data indicate that the immunosuppressive effects of cyclophosphamide may be associated with a reduction in both cell types.<\/jats:p>","DOI":"10.1002\/art.1780180113","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:28:15Z","timestamp":1171470495000},"page":"67-75","source":"Crossref","is-referenced-by-count":57,"title":["The effect of cyclophosphamide on b and t lymphocytes in patients with connective tissue diseases"],"prefix":"10.1002","volume":"18","author":[{"given":"Eric R.","family":"Hurd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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