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There was no accentuation of frequency in either sex in the 10\u2010 to 14\u2010year age group. The distribution of age of onset was bimodal in both monarticular and polyarticular onset of disease, but no particular modal age of onset was seen with systemic onset of disease. It is possible that these data reflect that JRA is not a homogeneous disease, or that there are age\u2010sex related differences in host susceptibility or pathogenoc agents.<\/jats:p>","DOI":"10.1002\/art.1780180309","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:28:00Z","timestamp":1171470480000},"page":"251-255","source":"Crossref","is-referenced-by-count":73,"title":["Pathogenic implications of age of onset in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"18","author":[{"given":"Donita B.","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross E.","family":"Petty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)32898-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1542\/peds.50.6.940","article-title":"Juvenile rheumatoid arthritis: a review.","volume":"50","author":"Schaller J","year":"1972","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780120204"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780100202"},{"key":"e_1_2_1_6_2","first-page":"88","article-title":"Serological patterns in juvenile rheumatoid arthritis.","volume":"19","author":"Sievers K","year":"1963","journal-title":"Rheumatism"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80293-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80260-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1542\/peds.38.5.916","article-title":"Sex differences in incidence of antinuclear factors in juvenile rheumatoid arthritis.","volume":"38","author":"JJ II","year":"1966","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)31475-4"},{"key":"e_1_2_1_11_2","first-page":"1","article-title":"A prognostic study of juvenile rheumatoid arthritis. Analysis of 544 cases.","volume":"166","author":"Laaksonen AL","year":"1966","journal-title":"Acta Paediatr Scand [Suppl]"},{"key":"e_1_2_1_12_2","first-page":"712","article-title":"Criteria for the classification of juvenile rheumatoid arthritis.","volume":"23","author":"Brewer EJ","year":"1972","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(67)80259-2"},{"key":"e_1_2_1_14_2","first-page":"26","volume-title":"Age and the rheumatic diseases, Population Studies of the Rheumatic Diseases","author":"Wood PHN","year":"1966"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(46)80102-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/rhe1.1957.3.issue-1-4.18"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.24.2.116"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780180309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780180309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T22:57:05Z","timestamp":1700693825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780180309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,5]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1975,5]]}},"alternative-id":["10.1002\/art.1780180309"],"URL":"https:\/\/doi.org\/10.1002\/art.1780180309","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,5]]}}}