{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:34:30Z","timestamp":1779114870180,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":11102,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1975,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two proteins in the properdin system, properdin and factor B, and complement components C4 and C3 were measured by radial immunodiffusion in serums and synovial fluids from 21 patients with rheumatoid arthritis (RA) and positive tests for rheumatoid factor, 9 patients with seronegative RA, and 10 with degenerative joint disease. In addition to depressions of synovial fluid C4 which correlated with lowered C3 in seropositive RA, consistent with activation of the classic pathway, low synovial fluid levels of factor B and properdin in seropositive RA indicate intraarticular activation of the properdin pathway as well.<\/jats:p>","DOI":"10.1002\/art.1780180401","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:27:57Z","timestamp":1171470477000},"page":"289-296","source":"Crossref","is-referenced-by-count":32,"title":["Depressed synovial fluid levels of properdin and properdin factor b in patients with rheumatoid arthritis"],"prefix":"10.1002","volume":"18","author":[{"given":"Shaun","family":"Ruddy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas T.","family":"Fearon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Frank","family":"Austen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00000441-195108000-00009","article-title":"Serum complement in rheumatoid arthritis.","volume":"222","author":"Vaughan JH","year":"1951","journal-title":"Am J Med Sci"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1958.tb04900.x"},{"key":"e_1_2_1_4_2","first-page":"439","article-title":"Serum complement levels in rheumatoid arthritis.","volume":"24","author":"Schubert AF","year":"1965","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140206"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105013"},{"key":"e_1_2_1_7_2","first-page":"1","article-title":"Studies on synovial fluid in arthritis. I. The total complement activity","volume":"479","author":"Hedberg H","year":"1967","journal-title":"Acta Med Scand"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780080206"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130601"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106531"},{"key":"e_1_2_1_11_2","first-page":"141","article-title":"Immuno\u2010fluorescent localization of the third and the fourth component of complement in synovial tissue from patients with rheumatoid arthritis.","volume":"69","author":"Rodman WS","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140111"},{"key":"e_1_2_1_13_2","first-page":"511","article-title":"Presence of aggregated \u03b3G\u2010globulin in certain rheumatoid synovial effusions.","volume":"2","author":"Hannestad K","year":"1967","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_14_2","first-page":"689","article-title":"Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis: partial characterization and relationship to lowered complement levels.","volume":"6","author":"Winchester RJ","year":"1970","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1956.tb40127.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.1.44"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4049\/jimmunol.107.4.1200","article-title":"Functional relationship of factor B in the properdin system to C3 proactivator of human serum.","volume":"107","author":"Goodkofsky I","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.2.426"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(195902)2:1<16::AID-ART1780020104>3.0.CO;2-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195804102581503"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90244-6"},{"key":"e_1_2_1_22_2","first-page":"231","volume-title":"Complement component levels in hereditary angio\u2010neurotic edema and isolated C\u20322 deficiency in man, Mechanisms of Inflammation Induced by Immune Reactions","author":"Ruddy S","year":"1968"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197210262871701"},{"key":"e_1_2_1_24_2","volume-title":"Introduction to Statistical Analysis","author":"Dixon WJ","year":"1969"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140503"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197406062902304"},{"key":"e_1_2_1_27_2","first-page":"410a","article-title":"Direct measurement of intraarticular hypercatabolism of third complement component (C3) in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).","volume":"14","author":"Ruddy S","year":"1971","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"259s","DOI":"10.1084\/jem.134.3.259","article-title":"Hemolytic assay of the ninth complement component: elevation and depletion in rheumatic diseases.","volume":"134","author":"Ruddy S","year":"1971","journal-title":"J Exp Med"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106119"},{"key":"e_1_2_1_30_2","unstructured":"FearonDT RuddyS SchurPH et al: Activation of the properdin pathway of complement in patients with gram\u2010negative bacteremia.N Engl J Med(in press)"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12679439"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.5.1249"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.2.355"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.4.1003"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"90s","DOI":"10.1084\/jem.134.3.90","article-title":"The C3 activator system: an alternate pathway of complement activation.","volume":"134","author":"G\u00f6tze O","year":"1971","journal-title":"J Exp Med"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.6.1305"},{"key":"e_1_2_1_37_2","first-page":"742","article-title":"C3b inactivator of man. II. Fragments produced by C3b inactivator cleavage of cell\u2010bound or fluid phase C3b.","volume":"107","author":"Ruddy S","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170315"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780180401","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780180401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:16:00Z","timestamp":1700694960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780180401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1975,7]]}},"alternative-id":["10.1002\/art.1780180401"],"URL":"https:\/\/doi.org\/10.1002\/art.1780180401","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,7]]}}}