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The synovial fluid exhibited severe hypoxia, hypercapnia, and lactic acidosis. Methods were developed to estimate the oxygen saturation of blood in regional venous capillaries, the degree of periarticular sickling, changes in the viscosity of local blood, and the articular ratio of blood flow to oxygen utilization. The results suggest that local vascular insufficiency associated with sickling may affect host response to infection and efficacy of antibiotics. The <jats:italic>Salmonella<\/jats:italic> C<jats:sub>1<\/jats:sub> readily transformed to an L form on hypertonic medium, thus acquiring resistance to ampicillin and other cell\u2010wall inhibitors.<\/jats:p>","DOI":"10.1002\/art.1780180408","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:27:57Z","timestamp":1171470477000},"page":"339-345","source":"Crossref","is-referenced-by-count":8,"title":["Septic arthritis in sickle\u2010cell thalassemia"],"prefix":"10.1002","volume":"18","author":[{"given":"Donald W.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"PalmerDW EllmanMH: Septic arthritis and Reiter's syndrome in sickle\u2010cell disorders: Case reports and implications for management.South Med J(in press)"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197103000-00002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197405000-00003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196708000-00011"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196808292790904"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196910232811703"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(71)80048-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197202000-00008"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304192881601"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1956.00250200021002"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1182\/blood.V24.1.25.25","article-title":"Rate of sickling of red cells during deoxygenation of blood from persons with various sickling disorders.","volume":"24","author":"Charache S","year":"1964","journal-title":"Blood"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/44.1.1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-2-203"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.124.1.99"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(70)80078-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140407"},{"key":"e_1_2_1_18_2","first-page":"789","article-title":"Effect of oxygen tension and of pH on the sickling and mechanical fragility of erythrocytes from patients with sickle cell anemia and the sickle cell trait.","volume":"37","author":"Lange RD","year":"1951","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_19_2","volume-title":"The Red Cell. 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