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Superficial cartilage showed a finely granular electron\u2010dense material. This material, which may be protein, possibly of enzyme or immunoglobulin origin, also surrounded some elastic fibrils. Findings of predominantly superficial changes and the multisystem disease in the present patient and in many others suggest that the cartilage destruction is part of a systemic inflammatory disease.<\/jats:p>","DOI":"10.1002\/art.1780180614","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:50:33Z","timestamp":1171475433000},"page":"617-625","source":"Crossref","is-referenced-by-count":12,"title":["Relapsing polychondritis"],"prefix":"10.1002","volume":"18","author":[{"given":"Stephen R.","family":"Shaul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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