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However elevated transaminase levels occurred with low salicylate levels and during inactive stages, and were inconstant in individual patients. Marked transaminase abnormalities were transient and appeared unpredictably in individual patients. Some factor in addition to salicylate concentration must be involved in raising serum transaminase levels. No evidence of chronic hepatotoxicity was noted.<\/jats:p>","DOI":"10.1002\/art.1780190121","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:48:48Z","timestamp":1171475328000},"page":"115-118","source":"Crossref","is-referenced-by-count":28,"title":["Correlations between transaminase concentrations and serum salicylate concentration in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"19","author":[{"suffix":"III","given":"John J.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-93-22671"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5806.167"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-1-1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-1-74"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-6-773_1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5759.428"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160102"},{"key":"e_1_2_1_9_2","first-page":"495","article-title":"Effects of salicylates on liver function in juvenile rheumatoid arthritis","volume":"17","author":"Athreya BH","year":"1974","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1542\/peds.50.6.940","article-title":"Juvenile rheumatoid arthritis: a review","volume":"50","author":"Schaller J","year":"1972","journal-title":"Pediatrics"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0570301"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/clinchem\/8.4.343","article-title":"Serum glutamic\u2010oxaloacetic transaminase activity","volume":"8","author":"Amador E","year":"1962","journal-title":"Clin Chem"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/34.4_ts.381"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80324-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(71)80054-9"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/185935a0"},{"key":"e_1_2_1_17_2","first-page":"128","article-title":"The effect of chronic administration of acetylsalicylic acid on the rabbit's liver","volume":"9","author":"Kalczak M","year":"1970","journal-title":"Pol Med J"},{"key":"e_1_2_1_18_2","first-page":"64","article-title":"Structure of hepatic microbodies in rats treated with acetylsalicylic acid, clofibrate, and dimethrin","volume":"30","author":"Hruban Z","year":"1974","journal-title":"Lab Invest"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-1-103"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780190121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780190121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T06:57:39Z","timestamp":1700722659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780190121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,1]]}},"alternative-id":["10.1002\/art.1780190121"],"URL":"https:\/\/doi.org\/10.1002\/art.1780190121","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,1]]}}}