{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:50Z","timestamp":1760188850662},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":10816,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1976,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two patients with hereditary homozygous C2 deficiency are described. They showed many similar clinical features. Both had discoid\u2010like skin rashes and serologic abnormalities consistent with SLE, but neither had evidence of involvement of any organ other than skin. Although biopsy of these lesions revealed expected changes by light microscopy, typical immunofluorescent findings were not present. The presence of the HL\u2010A haplotype 10,W18 was seen in both families and was associated with the C2 deficiency gene. The 2 patients were mutually nonreactive in MLC tests and both were found to be homozygous for the LD7a type.<\/jats:p>","DOI":"10.1002\/art.1780190302","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:45:49Z","timestamp":1171475149000},"page":"517-522","source":"Crossref","is-referenced-by-count":31,"title":["Hereditary C2 deficiency. Association with skin lesions resembling the discoid lesion of systemic lupus erythematosus"],"prefix":"10.1002","volume":"19","author":[{"given":"Richard","family":"Stern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu Man","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merilena","family":"Fotino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Agnello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry G.","family":"Kunkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105403"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4049\/jimmunol.98.1.72","article-title":"Hereditary deficiency of the second component of complement in man: further observations on a second kindred","volume":"95","author":"Klemperer MR","year":"1967","journal-title":"J Immunol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.4049\/jimmunol.101.6.1176","article-title":"Studies of an additional kindred with hereditary deficiency of the second component of human complement and discription of a new method for the quantitation of C2","volume":"101","author":"Cooper NR","year":"1968","journal-title":"J Immunol"},{"key":"e_1_2_1_5_2","first-page":"943","article-title":"Hereditary deficiency of the second component of complement (C2) in man: correlation of C2 hemolytic activity with immunochemical measurements of C2 protein","volume":"18","author":"Ruddy S","year":"1970","journal-title":"Immunology"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.4049\/jimmunol.108.3.837","article-title":"Hereditary C2 deficiency with some manifestations of systemic lupus erythematosus","volume":"108","author":"Agnello V","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1963.12.103"},{"key":"e_1_2_1_8_2","first-page":"305","article-title":"Variable patterns of immunoglobulin and complement deposition in the kidneys of patients with systemic lupus erythematosus","volume":"56","author":"Koffler D","year":"1969","journal-title":"Am J Pathol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.134.1.294"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197103000-00005"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.4.1108"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.2.495"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90537-9"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107337"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-3-323"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-3-420"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/jid.1963.140","article-title":"The application of the fluorescent antibody technique to the investigation of lupus erythematosus and various dermatoses","volume":"41","author":"Burnham TK","year":"1963","journal-title":"J Invest Dermatol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780090105"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.141.6.1464"},{"key":"e_1_2_1_20_2","first-page":"413A","article-title":"Association of complement deficiencies of the HL\u2010A system","volume":"23","author":"Schur PH","year":"1975","journal-title":"Clin Res"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1145185"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90970-7"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.6.1591"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.4.1019"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60253-9"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196904172801610"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780190302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780190302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:18:20Z","timestamp":1700723900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780190302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,5]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1976,5]]}},"alternative-id":["10.1002\/art.1780190302"],"URL":"https:\/\/doi.org\/10.1002\/art.1780190302","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,5]]}}}