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Depression of cell\u2010mediated immunity, determined by lymphocyte blastogenic response to mitogens, was associated with the clinical expression of illness. In contrast, auto\u2010reactive antilymphocyte antibodies and lymphocyte tubuloreticular structures were found in both clinically affected and unaffected subjects and were more prominently associated with the presence of other serologic abnormalities. No evidence of antigens or cell surface determinants unique to affected sibs was encountered.<\/jats:p>","DOI":"10.1002\/art.1780190306","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:45:49Z","timestamp":1171475149000},"page":"545-554","source":"Crossref","is-referenced-by-count":47,"title":["Immunologic observations on 9 sets of twins either concordant or discordant for SLE"],"prefix":"10.1002","volume":"19","author":[{"given":"Sidney R.","family":"Block","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Lockshin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Winfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc E.","family":"Weksler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakatsu","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Winchester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Mellors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L.","family":"Christian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"267","volume-title":"Family, twin, and genetic studies: a general review illustrated by systemic lupus erythematosus, Population Studies of the Rheumatic Diseases","author":"Masi AT","year":"1968"},{"key":"e_1_2_1_3_2","first-page":"743","article-title":"Family studies in systemic lupus erythematosus","volume":"2","author":"Leonhardt ETG","year":"1967","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90261-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.126.4.607"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196407232710401"},{"key":"e_1_2_1_7_2","volume-title":"Immunological status of patients with rheumatic disease. 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